Leptin in hippocampus mediates benefits of mild exercise by an antioxidant on neurogenesis and memory

Regular exercise and dietary supplements with antioxidants each have the potential to improve cognitive function and attenuate cognitive decline, and, in some cases, they enhance each other. Our current results reveal that low-intensity exercise (mild exercise, ME) and the natural antioxidant carote...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-05, Vol.116 (22), p.10988-10993
Hauptverfasser:	Yook, Jang Soo, Rakwal, Randeep, Shibato, Junko, Takahashi, Kanako, Koizumi, Hikaru, Shima, Takeru, Ikemoto, Mitsushi J., Oharomari, Leandro K., McEwen, Bruce S., Soya, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Antioxidants Antioxidants - pharmacology Astaxanthin Bioinformatics Biological Sciences Cell Line, Tumor Cell lines Cell Survival - drug effects Cell viability Cognition Cognitive ability Deoxyribonucleic acid Diet Dietary supplements DNA DNA chips DNA microarrays Gene expression Hippocampus Hippocampus - drug effects Hippocampus - metabolism Humans LEP gene Leptin Leptin - metabolism Memory Memory tasks Mice Neurogenesis Neurogenesis - drug effects Physical Conditioning, Animal Spatial analysis Spatial memory Spatial Memory - drug effects Stat3 protein Ventricle (lateral) Xanthophylls - pharmacology
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