Role of Phosphorylated AMP-Activated Protein Kinase (AMPK) in Myocardial Insulin Resistance After Myocardial Ischemia-Reperfusion During Cardiopulmonary Bypass Surgery in Dogs

BACKGROUND The aim of this study was to determine the role of AMP-activated protein kinase (AMPK) in myocardial insulin resistance after myocardial ischemia-reperfusion during cardiopulmonary bypass surgery in dogs. MATERIAL AND METHODS Twenty-four mongrel dogs were randomly assigned to 4 groups. Th...

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Veröffentlicht in:	Medical science monitor 2019-06, Vol.25, p.4149-4158
Hauptverfasser:	Zhang, Deng-Shen, Liang, Gui-You, Liu, Da-Xing, Yu, Jie, Wang, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP-Activated Protein Kinases - metabolism Animal Study Animals Cardioplegic Solutions Cardiopulmonary Bypass - methods Cardiopulmonary Bypass - veterinary China Coronary Artery Disease - metabolism Coronary Artery Disease - surgery Dogs Female Glucose - metabolism Glucose Transporter Type 4 - metabolism Heart Ventricles - physiopathology Insulin Resistance - physiology Ischemia - metabolism Male Myocardial Ischemia - metabolism Myocardial Reperfusion - methods Myocardial Reperfusion Injury - metabolism Myocardium - metabolism Phosphorylation Pyrazoles - pharmacology Pyrimidines - pharmacology Ribonucleotides - pharmacology
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