Nanoformulated ABT-199 to effectively target Bcl-2 at mitochondrial membrane alleviates airway inflammation by inducing apoptosis

Elimination of airway inflammatory cells is essential for asthma control. As Bcl-2 protein is highly expressed on the mitochondrial outer membrane in inflammatory cells, we chose a Bcl-2 inhibitor, ABT-199, which can inhibit airway inflammation and airway hyperresponsiveness by inducing inflammatory...

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Veröffentlicht in:	Biomaterials 2019-02, Vol.192, p.429-439
Hauptverfasser:	Tian, Bao-Ping, Li, Fangyuan, Li, Ruiqing, Hu, Xi, Lai, Tian-Wen, Lu, Jingxiong, Zhao, Yun, Du, Yang, Liang, Zeyu, Zhu, Chen, Shao, Wei, Li, Wen, Chen, Zhi-Hua, Sun, Xiaolian, Chen, Xiaoyuan, Ying, Songmin, Ling, Daishun, Shen, Huahao
Format:	Artikel
Sprache:	eng
Schlagworte:	ABT-199 Allergic airway inflammation animal models Animals apoptosis Apoptosis - drug effects asthma Asthma - drug therapy Bcl-2 biocompatibility Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Bridged Bicyclo Compounds, Heterocyclic - therapeutic use Cell Line cell viability Drug Delivery Systems epithelium hypersecretion Hypersensitivity - drug therapy inflammation Inflammation - drug therapy liver function Mice Mitochondria mitochondrial membrane Mitochondrial Membranes - drug effects mucus nanocarriers Nanotechnology Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Sulfonamides - administration & dosage Sulfonamides - therapeutic use Targeted drug delivery
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