The role of aurora A and polo-like kinases in high-risk lymphomas

High-risk lymphomas (HRLs) are associated with dismal outcomes and remain a therapeutic challenge. Recurrent genetic and molecular alterations, including c-myc expression and aurora A kinase (AAK) and polo-like kinase-1 (PLK1) activation, promote cell proliferation and contribute to the highly aggre...

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Veröffentlicht in:	Blood advances 2019-06, Vol.3 (11), p.1778-1787
Hauptverfasser:	Murga-Zamalloa, Carlos, Inamdar, Kedar V., Wilcox, Ryan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aurora Kinase A - metabolism Cell Cycle Proteins - metabolism Humans Lymphoma, B-Cell - enzymology Lymphoma, B-Cell - pathology Lymphoma, B-Cell - therapy Lymphoma, T-Cell - enzymology Lymphoma, T-Cell - pathology Lymphoma, T-Cell - therapy Polo-Like Kinase 1 Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-myc - metabolism Review Risk Factors Signal Transduction
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