Modeling the Effect of TNF-α upon Drug-Induced Toxicity in Human, Tissue-Engineered Myobundles

A number of significant muscle diseases, such as cachexia, sarcopenia, systemic chronic inflammation, along with inflammatory myopathies share TNF-α-dominated inflammation in their pathogenesis. In addition, inflammatory episodes may increase susceptibility to drug toxicity. To assess the effect of...

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Veröffentlicht in:	Annals of biomedical engineering 2019-07, Vol.47 (7), p.1596-1610
Hauptverfasser:	Davis, Brittany N. J., Santoso, Jeffrey W., Walker, Michaela J., Oliver, Catherine E., Cunningham, Michael M., Boehm, Christian A., Dawes, Danielle, Lasater, Samantha L., Huffman, Kim, Kraus, William E., Truskey, George A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Cachexia Classical Mechanics Doxorubicin Inflammation Maturation Muscles Musculoskeletal system Pathogenesis Sarcopenia Skeletal muscle Synergistic effect Tetanus Tissue engineering Toxicity Tumor necrosis factor-α
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