Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus

Microglial activation has been recognized as a major contributor to inflammation of the epileptic brain. Seizures are commonly accompanied by remarkable microgliosis and loss of neurons. In this study, we utilize the CX3CR1GFP/+ CCR2RFP/+ genetic mouse model, in which CX3CR1+ resident microglia and...

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Veröffentlicht in:	Glia 2019-08, Vol.67 (8), p.1434-1448
Hauptverfasser:	Feng, Lijie, Murugan, Madhuvika, Bosco, Dale B., Liu, Yong, Peng, Jiyun, Worrell, Gregory A., Wang, Hai‐Long, Ta, Lauren E., Richardson, Jason R., Shen, Yuxian, Wu, Long‐Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Attenuation Brain Calcium-Binding Proteins - metabolism CC chemokine receptors CCR2 protein Cell activation Cell Death Cell Proliferation Cerebrospinal fluid colony stimulating factor 1 receptor Convulsions & seizures CX3C Chemokine Receptor 1 - genetics CX3C Chemokine Receptor 1 - metabolism CX3CR1 protein Disease Models, Animal Epilepsy Gliosis - etiology Gliosis - physiopathology Hippocampus Hippocampus - physiopathology Infiltration Kainic Acid Male Mice, Inbred C57BL Mice, Transgenic Microfilament Proteins - metabolism Microglia Microglia - physiology Monocyte chemoattractant protein 1 Monocytes Monocytes - physiology Neuroimaging Neurons - physiology Neuroprotection Pharmacology Physical characteristics proliferation Receptor, Macrophage Colony-Stimulating Factor - metabolism Receptors, CCR2 - genetics Receptors, CCR2 - metabolism Recording Seizures Status Epilepticus - complications Status Epilepticus - physiopathology Therapeutic applications Tissue Culture Techniques
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