Downregulation of CKS1B restrains the proliferation, migration, invasion and angiogenesis of retinoblastoma cells through the MEK/ERK signaling pathway

Retinoblastoma (RB) is a common neoplasm that is exhibited in individuals globally. Increasing evidence demonstrated that cyclin‑dependent kinase regulatory subunit 1B (CKS1B) may be involved in the pathogenesis of various tumor types, including multiple myeloma and breast cancer. In the present stu...

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Veröffentlicht in:	International journal of molecular medicine 2019-07, Vol.44 (1), p.103-114
Hauptverfasser:	Zeng, Zhou, Gao, Zhao-Lin, Zhang, Zhi-Pei, Jiang, Hai-Bo, Yang, Chang-Quan, Yang, Jie, Xia, Xiao-Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Antigens Apoptosis Breast cancer Cancer Cancer therapies CDC2-CDC28 Kinases - blood CDC2-CDC28 Kinases - genetics Cell cycle Cell Line, Tumor Cell Proliferation Child, Preschool Cyclin-dependent kinases Down-Regulation Educational services industry Endothelium Female Fibroblast growth factors Gene expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Hospitals Humans Infant Kinases Lymphomas Male MAP Kinase Signaling System Medical prognosis Metastasis Mitogens Multiple myeloma Neoplasm Invasiveness Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pathology Polymerase chain reaction Protein kinases Proteins Retina Retinoblastoma Retinoblastoma - genetics Retinoblastoma - metabolism Retinoblastoma - pathology RNA Signal transduction Therapeutics Tumors Vascular endothelial growth factor
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