Real-world outcomes of observation and treatment in diabetic macular edema with very good visual acuity: the OBTAIN study
Aims To describe and compare the functional and anatomical outcomes of untreated and treated diabetic macular edema (DME) in eyes with very good baseline visual acuity (VA) in a real-world setting. Methods A 12-month, retrospective, multicenter, observational cohort study, including DME patients wit...
Gespeichert in:
| Veröffentlicht in: | Acta diabetologica 2019-07, Vol.56 (7), p.777-784 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 784 |
|---|---|
| container_issue | 7 |
| container_start_page | 777 |
| container_title | Acta diabetologica |
| container_volume | 56 |
| creator | Busch, Catharina Fraser-Bell, Samantha Zur, Dinah Rodríguez-Valdés, Patricio J. Cebeci, Zafer Lupidi, Marco Fung, Adrian T. Gabrielle, Pierre-Henry Giancipoli, Ermete Chaikitmongkol, Voraporn Okada, Mali Laíns, Inês Santos, Ana Rita Kunavisarut, Paradee Sala-Puigdollers, Anna Chhablani, Jay Ozimek, Malgorzata Hilely, Assaf Unterlauft, Jan Darius Loewenstein, Anat Iglicki, Matias Rehak, Matus |
| description | Aims
To describe and compare the functional and anatomical outcomes of untreated and treated diabetic macular edema (DME) in eyes with very good baseline visual acuity (VA) in a real-world setting.
Methods
A 12-month, retrospective, multicenter, observational cohort study, including DME patients with baseline visual acuity (VA) ≤ 0.1 logMAR (≥ 20/25 Snellen) and central subfield thickness (CST) > 250 µm with intra- and/or subretinal fluid seen on optical coherence tomography.
Results
A total of 249 eyes were included, of which 155 were treated and 94 were non-treated during follow-up. Most eyes maintained vision (VA gain or VA loss |
| doi_str_mv | 10.1007/s00592-019-01310-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6558052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2238025851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c565t-b281a76012df9290c3c798f4cacb49c362fcc185741cebab59bf1488c459fb033</originalsourceid><addsrcrecordid>eNp9kk9v1DAQxS0EosvCF-CALHGBQ2D8L4k5IC0V0EorKqFythzH2XWVxMV2tko_PS4pBXrowbLk-c2b8dND6CWBdwSgeh8BhKQFEJkPI1BcP0IrwhktBGXsMVqB5FAITuURehbjBQChFaufoiMGEhhnfIXm71b3xZUPfYv9lIwfbMS-w76JNhx0cn7EemxxClanwY4JuxG3Tjc2OYMHbaZeB2xbO2h85dIeH2yY8c77Fh9cnHSPM-LS_AGnvcVnn843p99wTFM7P0dPOt1H--L2XqMfXz6fH58U27Ovp8ebbWFEKVLR0Jroqsyrt52kEgwzlaw7brRpuDSspJ0xpBYVJ8Y2uhGy6Qiva8OF7BpgbI0-LrqXUzPY1uQ_BN2ry-AGHWbltVP_V0a3Vzt_UKUQNWQn1-jtIrC_13ay2aqbN6AlFUySA8nsm9thwf-cbExqcNHYvtej9VNUlMgyS9ZlmdHX99ALP4UxW6FoJoCKWpAHKSLzr2l2KVN0oUzwMQbb3e1JQN1kRS1ZUTkr6ndW1HVuevWvMXctf8KRAbYAMZfGnQ1_Zz8g-ws98cpo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2195742565</pqid></control><display><type>article</type><title>Real-world outcomes of observation and treatment in diabetic macular edema with very good visual acuity: the OBTAIN study</title><source>SpringerLink Journals - AutoHoldings</source><creator>Busch, Catharina ; Fraser-Bell, Samantha ; Zur, Dinah ; Rodríguez-Valdés, Patricio J. ; Cebeci, Zafer ; Lupidi, Marco ; Fung, Adrian T. ; Gabrielle, Pierre-Henry ; Giancipoli, Ermete ; Chaikitmongkol, Voraporn ; Okada, Mali ; Laíns, Inês ; Santos, Ana Rita ; Kunavisarut, Paradee ; Sala-Puigdollers, Anna ; Chhablani, Jay ; Ozimek, Malgorzata ; Hilely, Assaf ; Unterlauft, Jan Darius ; Loewenstein, Anat ; Iglicki, Matias ; Rehak, Matus</creator><creatorcontrib>Busch, Catharina ; Fraser-Bell, Samantha ; Zur, Dinah ; Rodríguez-Valdés, Patricio J. ; Cebeci, Zafer ; Lupidi, Marco ; Fung, Adrian T. ; Gabrielle, Pierre-Henry ; Giancipoli, Ermete ; Chaikitmongkol, Voraporn ; Okada, Mali ; Laíns, Inês ; Santos, Ana Rita ; Kunavisarut, Paradee ; Sala-Puigdollers, Anna ; Chhablani, Jay ; Ozimek, Malgorzata ; Hilely, Assaf ; Unterlauft, Jan Darius ; Loewenstein, Anat ; Iglicki, Matias ; Rehak, Matus ; International Retina Group ; For the International Retina Group</creatorcontrib><description>Aims
To describe and compare the functional and anatomical outcomes of untreated and treated diabetic macular edema (DME) in eyes with very good baseline visual acuity (VA) in a real-world setting.
Methods
A 12-month, retrospective, multicenter, observational cohort study, including DME patients with baseline visual acuity (VA) ≤ 0.1 logMAR (≥ 20/25 Snellen) and central subfield thickness (CST) > 250 µm with intra- and/or subretinal fluid seen on optical coherence tomography.
Results
A total of 249 eyes were included, of which 155 were treated and 94 were non-treated during follow-up. Most eyes maintained vision (VA gain or VA loss < 5 letters) at 12 months (treated: 58.1%; non-treated: 73.4%). In non-treated eyes with stable VA within the first 6 months, VA was maintained throughout the follow-up in most cases (86.3%). In non-treated eyes with VA loss ≥ 5 letters within 6 months (36.7%), further observation led to worse visual outcome than treatment (− 4.2 vs. − 7.8 letters,
p
= 0.013). In eyes in which treatment was initiated at baseline (
n
= 102), treatment with 8–12 anti-VEGF injections led to better visual outcome compared to treatment with less injections (− 0.3 ± 3.6 letters vs. − 3.8 ± 6.2 letters,
p
= 0.003).
Conclusion
In a real-world setting, the majority of DME patients with very good VA maintained vision at 12 months, regardless of whether the DME was treated or not. This study supports close observation of eyes with DME and very good VA with consideration of treatment when a one line drop in vision is observed.</description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-019-01310-z</identifier><identifier>PMID: 30903434</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Acuity ; Diabetes ; Diabetes mellitus ; Edema ; Endocrinology and metabolism ; Eye ; Human health and pathology ; Internal Medicine ; Life Sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original ; Original Article ; Patients ; Vascular endothelial growth factor ; Vision ; Visual acuity</subject><ispartof>Acta diabetologica, 2019-07, Vol.56 (7), p.777-784</ispartof><rights>The Author(s) 2019</rights><rights>Acta Diabetologica is a copyright of Springer, (2019). All Rights Reserved. © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright Springer Nature B.V. 2019</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-b281a76012df9290c3c798f4cacb49c362fcc185741cebab59bf1488c459fb033</citedby><cites>FETCH-LOGICAL-c565t-b281a76012df9290c3c798f4cacb49c362fcc185741cebab59bf1488c459fb033</cites><orcidid>0000-0002-6267-4663</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00592-019-01310-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00592-019-01310-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30903434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02625391$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Busch, Catharina</creatorcontrib><creatorcontrib>Fraser-Bell, Samantha</creatorcontrib><creatorcontrib>Zur, Dinah</creatorcontrib><creatorcontrib>Rodríguez-Valdés, Patricio J.</creatorcontrib><creatorcontrib>Cebeci, Zafer</creatorcontrib><creatorcontrib>Lupidi, Marco</creatorcontrib><creatorcontrib>Fung, Adrian T.</creatorcontrib><creatorcontrib>Gabrielle, Pierre-Henry</creatorcontrib><creatorcontrib>Giancipoli, Ermete</creatorcontrib><creatorcontrib>Chaikitmongkol, Voraporn</creatorcontrib><creatorcontrib>Okada, Mali</creatorcontrib><creatorcontrib>Laíns, Inês</creatorcontrib><creatorcontrib>Santos, Ana Rita</creatorcontrib><creatorcontrib>Kunavisarut, Paradee</creatorcontrib><creatorcontrib>Sala-Puigdollers, Anna</creatorcontrib><creatorcontrib>Chhablani, Jay</creatorcontrib><creatorcontrib>Ozimek, Malgorzata</creatorcontrib><creatorcontrib>Hilely, Assaf</creatorcontrib><creatorcontrib>Unterlauft, Jan Darius</creatorcontrib><creatorcontrib>Loewenstein, Anat</creatorcontrib><creatorcontrib>Iglicki, Matias</creatorcontrib><creatorcontrib>Rehak, Matus</creatorcontrib><creatorcontrib>International Retina Group</creatorcontrib><creatorcontrib>For the International Retina Group</creatorcontrib><title>Real-world outcomes of observation and treatment in diabetic macular edema with very good visual acuity: the OBTAIN study</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description>Aims
To describe and compare the functional and anatomical outcomes of untreated and treated diabetic macular edema (DME) in eyes with very good baseline visual acuity (VA) in a real-world setting.
Methods
A 12-month, retrospective, multicenter, observational cohort study, including DME patients with baseline visual acuity (VA) ≤ 0.1 logMAR (≥ 20/25 Snellen) and central subfield thickness (CST) > 250 µm with intra- and/or subretinal fluid seen on optical coherence tomography.
Results
A total of 249 eyes were included, of which 155 were treated and 94 were non-treated during follow-up. Most eyes maintained vision (VA gain or VA loss < 5 letters) at 12 months (treated: 58.1%; non-treated: 73.4%). In non-treated eyes with stable VA within the first 6 months, VA was maintained throughout the follow-up in most cases (86.3%). In non-treated eyes with VA loss ≥ 5 letters within 6 months (36.7%), further observation led to worse visual outcome than treatment (− 4.2 vs. − 7.8 letters,
p
= 0.013). In eyes in which treatment was initiated at baseline (
n
= 102), treatment with 8–12 anti-VEGF injections led to better visual outcome compared to treatment with less injections (− 0.3 ± 3.6 letters vs. − 3.8 ± 6.2 letters,
p
= 0.003).
Conclusion
In a real-world setting, the majority of DME patients with very good VA maintained vision at 12 months, regardless of whether the DME was treated or not. This study supports close observation of eyes with DME and very good VA with consideration of treatment when a one line drop in vision is observed.</description><subject>Acuity</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Edema</subject><subject>Endocrinology and metabolism</subject><subject>Eye</subject><subject>Human health and pathology</subject><subject>Internal Medicine</subject><subject>Life Sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Vascular endothelial growth factor</subject><subject>Vision</subject><subject>Visual acuity</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kk9v1DAQxS0EosvCF-CALHGBQ2D8L4k5IC0V0EorKqFythzH2XWVxMV2tko_PS4pBXrowbLk-c2b8dND6CWBdwSgeh8BhKQFEJkPI1BcP0IrwhktBGXsMVqB5FAITuURehbjBQChFaufoiMGEhhnfIXm71b3xZUPfYv9lIwfbMS-w76JNhx0cn7EemxxClanwY4JuxG3Tjc2OYMHbaZeB2xbO2h85dIeH2yY8c77Fh9cnHSPM-LS_AGnvcVnn843p99wTFM7P0dPOt1H--L2XqMfXz6fH58U27Ovp8ebbWFEKVLR0Jroqsyrt52kEgwzlaw7brRpuDSspJ0xpBYVJ8Y2uhGy6Qiva8OF7BpgbI0-LrqXUzPY1uQ_BN2ry-AGHWbltVP_V0a3Vzt_UKUQNWQn1-jtIrC_13ay2aqbN6AlFUySA8nsm9thwf-cbExqcNHYvtej9VNUlMgyS9ZlmdHX99ALP4UxW6FoJoCKWpAHKSLzr2l2KVN0oUzwMQbb3e1JQN1kRS1ZUTkr6ndW1HVuevWvMXctf8KRAbYAMZfGnQ1_Zz8g-ws98cpo</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Busch, Catharina</creator><creator>Fraser-Bell, Samantha</creator><creator>Zur, Dinah</creator><creator>Rodríguez-Valdés, Patricio J.</creator><creator>Cebeci, Zafer</creator><creator>Lupidi, Marco</creator><creator>Fung, Adrian T.</creator><creator>Gabrielle, Pierre-Henry</creator><creator>Giancipoli, Ermete</creator><creator>Chaikitmongkol, Voraporn</creator><creator>Okada, Mali</creator><creator>Laíns, Inês</creator><creator>Santos, Ana Rita</creator><creator>Kunavisarut, Paradee</creator><creator>Sala-Puigdollers, Anna</creator><creator>Chhablani, Jay</creator><creator>Ozimek, Malgorzata</creator><creator>Hilely, Assaf</creator><creator>Unterlauft, Jan Darius</creator><creator>Loewenstein, Anat</creator><creator>Iglicki, Matias</creator><creator>Rehak, Matus</creator><general>Springer Milan</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6267-4663</orcidid></search><sort><creationdate>20190701</creationdate><title>Real-world outcomes of observation and treatment in diabetic macular edema with very good visual acuity: the OBTAIN study</title><author>Busch, Catharina ; Fraser-Bell, Samantha ; Zur, Dinah ; Rodríguez-Valdés, Patricio J. ; Cebeci, Zafer ; Lupidi, Marco ; Fung, Adrian T. ; Gabrielle, Pierre-Henry ; Giancipoli, Ermete ; Chaikitmongkol, Voraporn ; Okada, Mali ; Laíns, Inês ; Santos, Ana Rita ; Kunavisarut, Paradee ; Sala-Puigdollers, Anna ; Chhablani, Jay ; Ozimek, Malgorzata ; Hilely, Assaf ; Unterlauft, Jan Darius ; Loewenstein, Anat ; Iglicki, Matias ; Rehak, Matus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-b281a76012df9290c3c798f4cacb49c362fcc185741cebab59bf1488c459fb033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acuity</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Edema</topic><topic>Endocrinology and metabolism</topic><topic>Eye</topic><topic>Human health and pathology</topic><topic>Internal Medicine</topic><topic>Life Sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Vascular endothelial growth factor</topic><topic>Vision</topic><topic>Visual acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Busch, Catharina</creatorcontrib><creatorcontrib>Fraser-Bell, Samantha</creatorcontrib><creatorcontrib>Zur, Dinah</creatorcontrib><creatorcontrib>Rodríguez-Valdés, Patricio J.</creatorcontrib><creatorcontrib>Cebeci, Zafer</creatorcontrib><creatorcontrib>Lupidi, Marco</creatorcontrib><creatorcontrib>Fung, Adrian T.</creatorcontrib><creatorcontrib>Gabrielle, Pierre-Henry</creatorcontrib><creatorcontrib>Giancipoli, Ermete</creatorcontrib><creatorcontrib>Chaikitmongkol, Voraporn</creatorcontrib><creatorcontrib>Okada, Mali</creatorcontrib><creatorcontrib>Laíns, Inês</creatorcontrib><creatorcontrib>Santos, Ana Rita</creatorcontrib><creatorcontrib>Kunavisarut, Paradee</creatorcontrib><creatorcontrib>Sala-Puigdollers, Anna</creatorcontrib><creatorcontrib>Chhablani, Jay</creatorcontrib><creatorcontrib>Ozimek, Malgorzata</creatorcontrib><creatorcontrib>Hilely, Assaf</creatorcontrib><creatorcontrib>Unterlauft, Jan Darius</creatorcontrib><creatorcontrib>Loewenstein, Anat</creatorcontrib><creatorcontrib>Iglicki, Matias</creatorcontrib><creatorcontrib>Rehak, Matus</creatorcontrib><creatorcontrib>International Retina Group</creatorcontrib><creatorcontrib>For the International Retina Group</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta diabetologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Busch, Catharina</au><au>Fraser-Bell, Samantha</au><au>Zur, Dinah</au><au>Rodríguez-Valdés, Patricio J.</au><au>Cebeci, Zafer</au><au>Lupidi, Marco</au><au>Fung, Adrian T.</au><au>Gabrielle, Pierre-Henry</au><au>Giancipoli, Ermete</au><au>Chaikitmongkol, Voraporn</au><au>Okada, Mali</au><au>Laíns, Inês</au><au>Santos, Ana Rita</au><au>Kunavisarut, Paradee</au><au>Sala-Puigdollers, Anna</au><au>Chhablani, Jay</au><au>Ozimek, Malgorzata</au><au>Hilely, Assaf</au><au>Unterlauft, Jan Darius</au><au>Loewenstein, Anat</au><au>Iglicki, Matias</au><au>Rehak, Matus</au><aucorp>International Retina Group</aucorp><aucorp>For the International Retina Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Real-world outcomes of observation and treatment in diabetic macular edema with very good visual acuity: the OBTAIN study</atitle><jtitle>Acta diabetologica</jtitle><stitle>Acta Diabetol</stitle><addtitle>Acta Diabetol</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>56</volume><issue>7</issue><spage>777</spage><epage>784</epage><pages>777-784</pages><issn>0940-5429</issn><eissn>1432-5233</eissn><abstract>Aims
To describe and compare the functional and anatomical outcomes of untreated and treated diabetic macular edema (DME) in eyes with very good baseline visual acuity (VA) in a real-world setting.
Methods
A 12-month, retrospective, multicenter, observational cohort study, including DME patients with baseline visual acuity (VA) ≤ 0.1 logMAR (≥ 20/25 Snellen) and central subfield thickness (CST) > 250 µm with intra- and/or subretinal fluid seen on optical coherence tomography.
Results
A total of 249 eyes were included, of which 155 were treated and 94 were non-treated during follow-up. Most eyes maintained vision (VA gain or VA loss < 5 letters) at 12 months (treated: 58.1%; non-treated: 73.4%). In non-treated eyes with stable VA within the first 6 months, VA was maintained throughout the follow-up in most cases (86.3%). In non-treated eyes with VA loss ≥ 5 letters within 6 months (36.7%), further observation led to worse visual outcome than treatment (− 4.2 vs. − 7.8 letters,
p
= 0.013). In eyes in which treatment was initiated at baseline (
n
= 102), treatment with 8–12 anti-VEGF injections led to better visual outcome compared to treatment with less injections (− 0.3 ± 3.6 letters vs. − 3.8 ± 6.2 letters,
p
= 0.003).
Conclusion
In a real-world setting, the majority of DME patients with very good VA maintained vision at 12 months, regardless of whether the DME was treated or not. This study supports close observation of eyes with DME and very good VA with consideration of treatment when a one line drop in vision is observed.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>30903434</pmid><doi>10.1007/s00592-019-01310-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6267-4663</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-5429 |
| ispartof | Acta diabetologica, 2019-07, Vol.56 (7), p.777-784 |
| issn | 0940-5429 1432-5233 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6558052 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Acuity Diabetes Diabetes mellitus Edema Endocrinology and metabolism Eye Human health and pathology Internal Medicine Life Sciences Medicine Medicine & Public Health Metabolic Diseases Original Original Article Patients Vascular endothelial growth factor Vision Visual acuity |
| title | Real-world outcomes of observation and treatment in diabetic macular edema with very good visual acuity: the OBTAIN study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T17%3A49%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Real-world%20outcomes%20of%20observation%20and%20treatment%20in%20diabetic%20macular%20edema%20with%20very%20good%20visual%20acuity:%20the%20OBTAIN%20study&rft.jtitle=Acta%20diabetologica&rft.au=Busch,%20Catharina&rft.aucorp=International%20Retina%20Group&rft.date=2019-07-01&rft.volume=56&rft.issue=7&rft.spage=777&rft.epage=784&rft.pages=777-784&rft.issn=0940-5429&rft.eissn=1432-5233&rft_id=info:doi/10.1007/s00592-019-01310-z&rft_dat=%3Cproquest_pubme%3E2238025851%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2195742565&rft_id=info:pmid/30903434&rfr_iscdi=true |