MHY2233 Attenuates Replicative Cellular Senescence in Human Endothelial Progenitor Cells via SIRT1 Signaling

Cardiovascular diseases (CVDs) are a major cause of death worldwide. Due to the prevalence of many side effects and incomplete recovery from pharmacotherapies, stem cell therapy is being targeted for the treatment of CVDs. Among the different types of stem cells, endothelial progenitor cells (EPCs)...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2019-01, Vol.2019 (2019), p.1-18
Hauptverfasser:	Dehua, Li, Kim, Da Yeon, Seong, Ha Jong, Yun, Jisoo, Lee, Dong Hyung, Moon, Hyung Ryong, Young Chung, Hae, Kwon, Sang-Mo, Lee, Na Kyung, Ji, Seung Taek, Jang, Woong Bi, Dahal Lamichane, Babita, Park, Ji Hye, Kim, Yeon-Ju, Baek, Sang Hong, Lamichane, Shreekrishna, Kang, Songhwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Apoptosis Benzoxazoles - pharmacology Bone marrow Cardiovascular disease Cardiovascular diseases Cell cycle Cell division Cellular Senescence - drug effects Cytotoxicity Endothelial Progenitor Cells - cytology Endothelial Progenitor Cells - drug effects Endothelial Progenitor Cells - metabolism Endothelium Fetal Blood - cytology Fetal Blood - diagnostic imaging Fetal Blood - metabolism Gene expression Growth factors Humans Hypertension Nitric oxide Oxidative stress Resveratrol - pharmacology Senescence Signal Transduction - drug effects Sirtuin 1 - metabolism Stem cells Transcription factors Transplantation Tumor proteins Umbilical cord
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