M1 Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder

The prefrontal cortex (PFC) integrates information from multiple inputs to exert top-down control allowing for appropriate responses in a given context. In psychiatric disorders such as posttraumatic stress disorder, PFC hyperactivity is associated with inappropriate fear in safe situations. We prev...

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Veröffentlicht in:	Biological psychiatry (1969) 2019-06, Vol.85 (12), p.989-1000
Hauptverfasser:	Maksymetz, James, Joffe, Max E., Moran, Sean P., Stansley, Branden J., Li, Brianna, Temple, Kayla, Engers, Darren W., Lawrence, J. Josh, Lindsley, Craig W., Conn, P. Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Fear extinction M1 muscarinic receptor Positive allosteric modulator Posttraumatic stress disorder Prefrontal cortex Synaptic plasticity
Online-Zugang:	Volltext
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