Nucleic Acid Vaccine Targeting Nogo-66 Receptor and Paired Immunoglobulin-Like Receptor B as an Immunotherapy Strategy for Spinal Cord Injury in Rats

Nogo-66 receptor (NgR) and paired immunoglobulin-like receptor B (PirB) are two common receptors of various myelin-associated inhibitors (MAIs) and, thus, play an important role in MAIs-induced inhibitory signalling of regeneration following spinal cord injury (SCI). Based on the concept of protecti...

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Veröffentlicht in:	Neurotherapeutics 2019-04, Vol.16 (2), p.381-393
Hauptverfasser:	Lu, Xiu-Min, Mao, Min, Xiao, Lan, Yu, Ying, He, Mei, Zhao, Guo-Yan, Tang, Jun-Jie, Feng, Shuang, Li, Sen, He, Cheng-Ming, Wang, Yong-Tang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Autoantigens Autoimmunity Biomedical and Life Sciences Biomedicine Central nervous system Central nervous system diseases Colony-stimulating factor Female Immunization Immunoglobulins Immunotherapy Immunotherapy - methods Injuries Leukocytes (granulocytic) Macrophages Myelin Nerve Regeneration - immunology Neurobiology Neurology Neurosciences Neurosurgery Nogo protein Nogo Receptor 1 - immunology Nucleic acids Original Original Article Rats Rats, Sprague-Dawley Recovery (Medical) Recovery of function Recovery of Function - immunology Regeneration Rodents Spinal cord injuries Spinal Cord Injuries - immunology Spinal Cord Injuries - therapy Vaccination Vaccines Vaccines, DNA - therapeutic use
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