Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction

RATIONALE:Hypoxic pulmonary vasoconstriction (HPV) optimizes systemic oxygen delivery by matching ventilation to perfusion. HPV is intrinsic to pulmonary artery smooth muscle cells (PASMCs). Hypoxia dilates systemic arteries, including renal arteries. Hypoxia is sensed by changes in mitochondrial-de...

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Veröffentlicht in:	Circulation research 2019-06, Vol.124 (12), p.1727-1746
Hauptverfasser:	Dunham-Snary, Kimberly J, Wu, Danchen, Potus, François, Sykes, Edward A, Mewburn, Jeffrey D, Charles, Rebecca L, Eaton, Philip, Sultanian, Richard A, Archer, Stephen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Electron Transport Complex I - metabolism Hypoxia - metabolism Hypoxia - pathology Lung - blood supply Lung - metabolism Male Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - metabolism NADH Dehydrogenase - metabolism Organ Culture Techniques Oxygen - analysis Oxygen - metabolism Protein Subunits - metabolism Rats Rats, Sprague-Dawley Vascular Resistance - physiology Vasoconstriction - physiology
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