Mechanisms of NAFLD development and therapeutic strategies

There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD), paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum of liver abnormalities from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but c...

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Veröffentlicht in:	Nature medicine 2018-07, Vol.24 (7), p.908-922
Hauptverfasser:	Friedman, Scott L., Neuschwander-Tetri, Brent A., Rinella, Mary, Sanyal, Arun J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/309/2144 692/308/2779/109 Abnormalities Animal models Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Cellular signal transduction Cirrhosis Clinical trials Comorbidity Diabetes mellitus Diagnosis Drug development Drug efficacy Fatty liver Gene expression Genetic aspects Infectious Diseases Liver Liver cancer Liver cirrhosis Liver diseases Medical schools Metabolic Diseases Metabolic disorders Metabolic syndrome Molecular Medicine Neurosciences Review Article Therapeutic applications Type 2 diabetes
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