Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironment

Chronic, low-grade inflammation increases the risk for atherosclerosis, cancer, and autoimmunity in diseases such as obesity and diabetes. Levels of CD4+ T helper 17 (Th17) cells, which secrete interleukin 17A (IL-17A), are increased in obesity and contribute to the inflammatory milieu; however, the...

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Veröffentlicht in:	The Journal of biological chemistry 2019-05, Vol.294 (22), p.8973-8990
Hauptverfasser:	Machacek, Miranda, Saunders, Harmony, Zhang, Zhen, Tan, Ee Phie, Li, Jibiao, Li, Tiangang, Villar, Maria T., Artigues, Antonio, Lydic, Todd, Cork, Gentry, Slawson, Chad, Fields, Patrick E.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetyl-CoA carboxylase (ACC) Acetyl-CoA Carboxylase - metabolism Acylation - drug effects Adult Aged Aged, 80 and over Animals CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - metabolism Cytokines - metabolism Fatty Acids - analysis Fatty Acids - biosynthesis Female Glycobiology and Extracellular Matrices Humans inflammation Interleukin-17 - genetics Interleukin-17 - metabolism lipid metabolism Lipidomics - methods Male Mice Mice, Inbred C57BL Middle Aged Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism O-linked N-acetylglucosamine (O-GlcNAc) obesity Obesity - metabolism Obesity - pathology Promoter Regions, Genetic Protein Binding Pyrans - pharmacology RAR-related orphan receptor gamma t variant T helper cells Th17 Th17 Cells - cytology Th17 Cells - metabolism Thiazoles - pharmacology Transcriptional Activation - drug effects type 2 diabetes
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