SAT-021 Efficacy of Vitamin D Supplementation According to Vitamin D Binding Protein Polymorphisms
The study aimed to determine the influence of DBP gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation. Out of 234 participants (126 females and 108 males), 146 had vitamin D deficiency (25(OH)D
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| Veröffentlicht in: | Journal of the Endocrine Society 2019-04, Vol.3 (Supplement_1) |
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| container_title | Journal of the Endocrine Society |
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| creator | Al-Daghri, Nasser Bukhari, Ihtisham Rikli, Maryam Abdi, Saba Ansari, Mohammed Abdulkhader, Mohammed Sabico, Shaun Hussain, Syed Danish Alenad, Amal Al-Saleh, Yousef Alokail, Majed |
| description | The study aimed to determine the influence of DBP gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation. Out of 234 participants (126 females and 108 males), 146 had vitamin D deficiency (25(OH)D |
| doi_str_mv | 10.1210/js.2019-SAT-021 |
| format | Article |
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DBP
gene were assessed. Post supplementation median 25(OH)D was significantly higher [61.2 (46.3-76.8) and 66.6 (53.2-83.7)] in participants with CC genotype of rs4588 and GG genotype of rs7041 than other genotypes (p<0.001). Participants with T allele are 2.9 (1.9-4.5) times more likely to be a non-responder (unable to achieve serum 25(OH)D post-supplementation) than those with G allele (p<0.001). Participants with A allele are 3.7 (2.1-6.6) times more likely to be a non-responder than those with C allele (p<0.001). Furthermore, participants with TT and TG are 6.2 and 4.2 times more likely to be a non-responder than those with the GG genotype (p-values <0.001) even after adjustments for age, gender, BMI, baseline 25(OH)D concentration and other alleles. Participants with AA and CA genotypes are 12.4 (1.4-110) and 4.1 (2.1-8.0) times more likely to be non-responders as compared to those with CC genotype but lost significance after adjustment. The SNPs, rs7041 and rs4588 variants of the
DBP
gene are associated with baseline 25(OH)D levels and modifies 25(OH)D response after vitamin D supplementation in Saudi adults.</description><identifier>ISSN: 2472-1972</identifier><identifier>EISSN: 2472-1972</identifier><identifier>DOI: 10.1210/js.2019-SAT-021</identifier><language>eng</language><publisher>Washington, DC: Endocrine Society</publisher><subject>Steroid Hormones and Receptors</subject><ispartof>Journal of the Endocrine Society, 2019-04, Vol.3 (Supplement_1)</ispartof><rights>Copyright © 2019 Endocrine Society 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1821-55c2ccfaa5afe3089b151b961b8a6ec263a72e85a1b727585209b768e6c5a3153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552145/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552145/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Al-Daghri, Nasser</creatorcontrib><creatorcontrib>Bukhari, Ihtisham</creatorcontrib><creatorcontrib>Rikli, Maryam</creatorcontrib><creatorcontrib>Abdi, Saba</creatorcontrib><creatorcontrib>Ansari, Mohammed</creatorcontrib><creatorcontrib>Abdulkhader, Mohammed</creatorcontrib><creatorcontrib>Sabico, Shaun</creatorcontrib><creatorcontrib>Hussain, Syed Danish</creatorcontrib><creatorcontrib>Alenad, Amal</creatorcontrib><creatorcontrib>Al-Saleh, Yousef</creatorcontrib><creatorcontrib>Alokail, Majed</creatorcontrib><title>SAT-021 Efficacy of Vitamin D Supplementation According to Vitamin D Binding Protein Polymorphisms</title><title>Journal of the Endocrine Society</title><description>The study aimed to determine the influence of DBP gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation. Out of 234 participants (126 females and 108 males), 146 had vitamin D deficiency (25(OH)D <50nmol/l) and were given 2000IU daily dose of vitamin D for 12 months. Two common single nucleotide polymorphisms (SNPs), (rs4588 and rs7041) of the
DBP
gene were assessed. Post supplementation median 25(OH)D was significantly higher [61.2 (46.3-76.8) and 66.6 (53.2-83.7)] in participants with CC genotype of rs4588 and GG genotype of rs7041 than other genotypes (p<0.001). Participants with T allele are 2.9 (1.9-4.5) times more likely to be a non-responder (unable to achieve serum 25(OH)D post-supplementation) than those with G allele (p<0.001). Participants with A allele are 3.7 (2.1-6.6) times more likely to be a non-responder than those with C allele (p<0.001). Furthermore, participants with TT and TG are 6.2 and 4.2 times more likely to be a non-responder than those with the GG genotype (p-values <0.001) even after adjustments for age, gender, BMI, baseline 25(OH)D concentration and other alleles. Participants with AA and CA genotypes are 12.4 (1.4-110) and 4.1 (2.1-8.0) times more likely to be non-responders as compared to those with CC genotype but lost significance after adjustment. The SNPs, rs7041 and rs4588 variants of the
DBP
gene are associated with baseline 25(OH)D levels and modifies 25(OH)D response after vitamin D supplementation in Saudi adults.</description><subject>Steroid Hormones and Receptors</subject><issn>2472-1972</issn><issn>2472-1972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVkFtrAjEQhUNpoWJ97mv-wGomu9nLS8Fae4FCBW1fw2xMNLK7WZK14L_vWqXYpxnOnHMYPkLugY2BA5vswpgzKKLldBUxDldkwJOMR1Bk_PpivyWjEHaM9dY4KZJkQMpzgs6NsQrVgTpDv2yHtW3oE13u27bStW467Kxr6FQp59e22dDOXdgebfMrLrzrdK8sXHWonW-3NtThjtwYrIIeneeQfD7PV7PX6P3j5W02fY8U5BwiIRRXyiAKNDpmeVGCgLJIocwx1YqnMWZc5wKhzHgmcsFZUWZprlMlMAYRD8nDqbfdl7Veq_5pj5Vsva3RH6RDK_9fGruVG_ctUyE4JMeCyalAeReC1-YvC0weMctdkEfMsocme2jxDwzXccs</recordid><startdate>20190430</startdate><enddate>20190430</enddate><creator>Al-Daghri, Nasser</creator><creator>Bukhari, Ihtisham</creator><creator>Rikli, Maryam</creator><creator>Abdi, Saba</creator><creator>Ansari, Mohammed</creator><creator>Abdulkhader, Mohammed</creator><creator>Sabico, Shaun</creator><creator>Hussain, Syed Danish</creator><creator>Alenad, Amal</creator><creator>Al-Saleh, Yousef</creator><creator>Alokail, Majed</creator><general>Endocrine Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20190430</creationdate><title>SAT-021 Efficacy of Vitamin D Supplementation According to Vitamin D Binding Protein Polymorphisms</title><author>Al-Daghri, Nasser ; Bukhari, Ihtisham ; Rikli, Maryam ; Abdi, Saba ; Ansari, Mohammed ; Abdulkhader, Mohammed ; Sabico, Shaun ; Hussain, Syed Danish ; Alenad, Amal ; Al-Saleh, Yousef ; Alokail, Majed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1821-55c2ccfaa5afe3089b151b961b8a6ec263a72e85a1b727585209b768e6c5a3153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Steroid Hormones and Receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Daghri, Nasser</creatorcontrib><creatorcontrib>Bukhari, Ihtisham</creatorcontrib><creatorcontrib>Rikli, Maryam</creatorcontrib><creatorcontrib>Abdi, Saba</creatorcontrib><creatorcontrib>Ansari, Mohammed</creatorcontrib><creatorcontrib>Abdulkhader, Mohammed</creatorcontrib><creatorcontrib>Sabico, Shaun</creatorcontrib><creatorcontrib>Hussain, Syed Danish</creatorcontrib><creatorcontrib>Alenad, Amal</creatorcontrib><creatorcontrib>Al-Saleh, Yousef</creatorcontrib><creatorcontrib>Alokail, Majed</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the Endocrine Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Daghri, Nasser</au><au>Bukhari, Ihtisham</au><au>Rikli, Maryam</au><au>Abdi, Saba</au><au>Ansari, Mohammed</au><au>Abdulkhader, Mohammed</au><au>Sabico, Shaun</au><au>Hussain, Syed Danish</au><au>Alenad, Amal</au><au>Al-Saleh, Yousef</au><au>Alokail, Majed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SAT-021 Efficacy of Vitamin D Supplementation According to Vitamin D Binding Protein Polymorphisms</atitle><jtitle>Journal of the Endocrine Society</jtitle><date>2019-04-30</date><risdate>2019</risdate><volume>3</volume><issue>Supplement_1</issue><issn>2472-1972</issn><eissn>2472-1972</eissn><abstract>The study aimed to determine the influence of DBP gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation. Out of 234 participants (126 females and 108 males), 146 had vitamin D deficiency (25(OH)D <50nmol/l) and were given 2000IU daily dose of vitamin D for 12 months. Two common single nucleotide polymorphisms (SNPs), (rs4588 and rs7041) of the
DBP
gene were assessed. Post supplementation median 25(OH)D was significantly higher [61.2 (46.3-76.8) and 66.6 (53.2-83.7)] in participants with CC genotype of rs4588 and GG genotype of rs7041 than other genotypes (p<0.001). Participants with T allele are 2.9 (1.9-4.5) times more likely to be a non-responder (unable to achieve serum 25(OH)D post-supplementation) than those with G allele (p<0.001). Participants with A allele are 3.7 (2.1-6.6) times more likely to be a non-responder than those with C allele (p<0.001). Furthermore, participants with TT and TG are 6.2 and 4.2 times more likely to be a non-responder than those with the GG genotype (p-values <0.001) even after adjustments for age, gender, BMI, baseline 25(OH)D concentration and other alleles. Participants with AA and CA genotypes are 12.4 (1.4-110) and 4.1 (2.1-8.0) times more likely to be non-responders as compared to those with CC genotype but lost significance after adjustment. The SNPs, rs7041 and rs4588 variants of the
DBP
gene are associated with baseline 25(OH)D levels and modifies 25(OH)D response after vitamin D supplementation in Saudi adults.</abstract><cop>Washington, DC</cop><pub>Endocrine Society</pub><doi>10.1210/js.2019-SAT-021</doi><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Oxford Journals Open Access Collection; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Steroid Hormones and Receptors |
| title | SAT-021 Efficacy of Vitamin D Supplementation According to Vitamin D Binding Protein Polymorphisms |
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