Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study
Purpose Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer. Methods Chemotherapy treatment (CT) group included...
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| Veröffentlicht in: | Breast cancer research and treatment 2019-07, Vol.176 (1), p.181-189 |
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| creator | Chen, Bihong T. Jin, Taihao Patel, Sunita K. Ye, Ningrong Ma, Huiyan Wong, Chi Wah Rockne, Russell C. Root, James C. Saykin, Andrew J. Ahles, Tim A. Holodny, Andrei I. Prakash, Neal Mortimer, Joanne Waisman, James Yuan, Yuan Li, Daneng Sedrak, Mina S. Vazquez, Jessica Katheria, Vani Dale, William |
| description | Purpose
Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer.
Methods
Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60–82 years) with stage I–III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Fourteen age- and sex-matched healthy controls (HC) underwent the same assessments at matched intervals. Three voxel-wise rs-fMRI parameters: amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity, were computed at each time point. The changes in rs-fMRI parameters from TP1 to TP2 for each group, the group differences in changes (the CT group vs. the HC group), and the group difference in the baseline rs-fMRI parameters were assessed. In addition, correlative analysis between the rs-fMRI parameters and neuropsychological testing scores was also performed.
Results
In the CT group, one brain region, which included parts of the bilateral subcallosal gyri and right anterior cingulate gyrus, displayed increased ALFF from TP1 to TP2 (cluster
p
-corrected = 0.024); another brain region in the left precuneus displayed decreased fALFF from TP1 to TP2 (cluster level
p
-corrected = 0.025). No significant changes in the rs-fMRI parameters from TP1 to TP2 were observed in the HC group. Although ALFF and fALFF alterations were observed only in the CT group, none of the between-group differences in rs-fMRI parameter changes reached statistical significance.
Conclusions
Our study results of ALFF and fALFF alterations in the chemotherapy-treated women suggest that adjuvant chemotherapy may affect intrinsic brain activity in older women with breast cancer. |
| doi_str_mv | 10.1007/s10549-019-05230-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6551279</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A587803022</galeid><sourcerecordid>A587803022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c572t-61884c2c86ba312c88489eb21c39eafeb58fa891aa6cc6dca6339ba48ab51c693</originalsourceid><addsrcrecordid>eNp9kt9r1TAUx4so7jr9B3yQgOBbZ360aeKDMIbTwcAXfQ6naXqbS5tck_SOvvuHm61z2wWREE7I-Xy_cA7fonhL8BnBuPkYCa4rWWKSb00ZLpdnxYbUDSsbSprnxQYT3pRcYH5SvIpxhzGWDZYvixOGpZAVp5vi95VLwbpoNWoDWIdAJ3uwaUF6ALc1EUGMXltIpkM3Ng0Iut18AJcyYCafBhNgv6Cs9GNnArrxk3Er2QYDMXPgtAmfEKC9HX1Co3dbm-bOOhhRzI_ldfGihzGaN_f1tPh5-eXHxbfy-vvXq4vz61LXDU0lJ0JUmmrBW2AkV1EJaVpKNJMGetPWogchCQDXmncaOGOyhUpAWxPNJTstPq---7mdTKdNnh1GtQ92grAoD1Ydd5wd1NYfFK9rQptbg_f3BsH_mk1MaufnkOeIitK8XIkJYY_UFkajrOt9NtOTjVqd16IRmGFKM3X2DyqfzkxWe2d6m_-PBB-eCAYDYxqiH-dkvYvHIF1BHXyMwfQPExKsbpOj1uSonBx1lxy1ZNG7p7t5kPyNSgbYCsTcyskIj7P_x_YPuZHRlw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2209790113</pqid></control><display><type>article</type><title>Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Chen, Bihong T. ; Jin, Taihao ; Patel, Sunita K. ; Ye, Ningrong ; Ma, Huiyan ; Wong, Chi Wah ; Rockne, Russell C. ; Root, James C. ; Saykin, Andrew J. ; Ahles, Tim A. ; Holodny, Andrei I. ; Prakash, Neal ; Mortimer, Joanne ; Waisman, James ; Yuan, Yuan ; Li, Daneng ; Sedrak, Mina S. ; Vazquez, Jessica ; Katheria, Vani ; Dale, William</creator><creatorcontrib>Chen, Bihong T. ; Jin, Taihao ; Patel, Sunita K. ; Ye, Ningrong ; Ma, Huiyan ; Wong, Chi Wah ; Rockne, Russell C. ; Root, James C. ; Saykin, Andrew J. ; Ahles, Tim A. ; Holodny, Andrei I. ; Prakash, Neal ; Mortimer, Joanne ; Waisman, James ; Yuan, Yuan ; Li, Daneng ; Sedrak, Mina S. ; Vazquez, Jessica ; Katheria, Vani ; Dale, William</creatorcontrib><description>Purpose
Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer.
Methods
Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60–82 years) with stage I–III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Fourteen age- and sex-matched healthy controls (HC) underwent the same assessments at matched intervals. Three voxel-wise rs-fMRI parameters: amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity, were computed at each time point. The changes in rs-fMRI parameters from TP1 to TP2 for each group, the group differences in changes (the CT group vs. the HC group), and the group difference in the baseline rs-fMRI parameters were assessed. In addition, correlative analysis between the rs-fMRI parameters and neuropsychological testing scores was also performed.
Results
In the CT group, one brain region, which included parts of the bilateral subcallosal gyri and right anterior cingulate gyrus, displayed increased ALFF from TP1 to TP2 (cluster
p
-corrected = 0.024); another brain region in the left precuneus displayed decreased fALFF from TP1 to TP2 (cluster level
p
-corrected = 0.025). No significant changes in the rs-fMRI parameters from TP1 to TP2 were observed in the HC group. Although ALFF and fALFF alterations were observed only in the CT group, none of the between-group differences in rs-fMRI parameter changes reached statistical significance.
Conclusions
Our study results of ALFF and fALFF alterations in the chemotherapy-treated women suggest that adjuvant chemotherapy may affect intrinsic brain activity in older women with breast cancer.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-019-05230-y</identifier><identifier>PMID: 30989462</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adjuvant treatment ; Age Factors ; Aged ; Aged, 80 and over ; Brain ; Brain mapping ; Breast cancer ; Breast Neoplasms - complications ; Breast Neoplasms - drug therapy ; Breast Neoplasms - epidemiology ; Cancer ; Cancer research ; Chemotherapy ; Chemotherapy, Adjuvant - adverse effects ; Chemotherapy, Adjuvant - methods ; Clinical Trial ; Cognition ; Cognitive ability ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - epidemiology ; Cognitive Dysfunction - etiology ; Computed tomography ; Cortex (parietal) ; Female ; Functional magnetic resonance imaging ; Health Care Surveys ; Humans ; Image Processing, Computer-Assisted ; Longitudinal Studies ; Magnetic Resonance Imaging ; Measuring techniques ; Medicine ; Medicine & Public Health ; Middle Aged ; Middle aged women ; Neuroimaging ; Neuroimaging - methods ; Oncology ; Oncology, Experimental ; Pilot Projects ; Psychology</subject><ispartof>Breast cancer research and treatment, 2019-07, Vol.176 (1), p.181-189</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Breast Cancer Research and Treatment is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-61884c2c86ba312c88489eb21c39eafeb58fa891aa6cc6dca6339ba48ab51c693</citedby><cites>FETCH-LOGICAL-c572t-61884c2c86ba312c88489eb21c39eafeb58fa891aa6cc6dca6339ba48ab51c693</cites><orcidid>0000-0002-3127-0711</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-019-05230-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-019-05230-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30989462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Bihong T.</creatorcontrib><creatorcontrib>Jin, Taihao</creatorcontrib><creatorcontrib>Patel, Sunita K.</creatorcontrib><creatorcontrib>Ye, Ningrong</creatorcontrib><creatorcontrib>Ma, Huiyan</creatorcontrib><creatorcontrib>Wong, Chi Wah</creatorcontrib><creatorcontrib>Rockne, Russell C.</creatorcontrib><creatorcontrib>Root, James C.</creatorcontrib><creatorcontrib>Saykin, Andrew J.</creatorcontrib><creatorcontrib>Ahles, Tim A.</creatorcontrib><creatorcontrib>Holodny, Andrei I.</creatorcontrib><creatorcontrib>Prakash, Neal</creatorcontrib><creatorcontrib>Mortimer, Joanne</creatorcontrib><creatorcontrib>Waisman, James</creatorcontrib><creatorcontrib>Yuan, Yuan</creatorcontrib><creatorcontrib>Li, Daneng</creatorcontrib><creatorcontrib>Sedrak, Mina S.</creatorcontrib><creatorcontrib>Vazquez, Jessica</creatorcontrib><creatorcontrib>Katheria, Vani</creatorcontrib><creatorcontrib>Dale, William</creatorcontrib><title>Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Purpose
Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer.
Methods
Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60–82 years) with stage I–III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Fourteen age- and sex-matched healthy controls (HC) underwent the same assessments at matched intervals. Three voxel-wise rs-fMRI parameters: amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity, were computed at each time point. The changes in rs-fMRI parameters from TP1 to TP2 for each group, the group differences in changes (the CT group vs. the HC group), and the group difference in the baseline rs-fMRI parameters were assessed. In addition, correlative analysis between the rs-fMRI parameters and neuropsychological testing scores was also performed.
Results
In the CT group, one brain region, which included parts of the bilateral subcallosal gyri and right anterior cingulate gyrus, displayed increased ALFF from TP1 to TP2 (cluster
p
-corrected = 0.024); another brain region in the left precuneus displayed decreased fALFF from TP1 to TP2 (cluster level
p
-corrected = 0.025). No significant changes in the rs-fMRI parameters from TP1 to TP2 were observed in the HC group. Although ALFF and fALFF alterations were observed only in the CT group, none of the between-group differences in rs-fMRI parameter changes reached statistical significance.
Conclusions
Our study results of ALFF and fALFF alterations in the chemotherapy-treated women suggest that adjuvant chemotherapy may affect intrinsic brain activity in older women with breast cancer.</description><subject>Adjuvant treatment</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain</subject><subject>Brain mapping</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant - adverse effects</subject><subject>Chemotherapy, Adjuvant - methods</subject><subject>Clinical Trial</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Computed tomography</subject><subject>Cortex (parietal)</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Health Care Surveys</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging</subject><subject>Measuring techniques</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Middle aged women</subject><subject>Neuroimaging</subject><subject>Neuroimaging - methods</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Pilot Projects</subject><subject>Psychology</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kt9r1TAUx4so7jr9B3yQgOBbZ360aeKDMIbTwcAXfQ6naXqbS5tck_SOvvuHm61z2wWREE7I-Xy_cA7fonhL8BnBuPkYCa4rWWKSb00ZLpdnxYbUDSsbSprnxQYT3pRcYH5SvIpxhzGWDZYvixOGpZAVp5vi95VLwbpoNWoDWIdAJ3uwaUF6ALc1EUGMXltIpkM3Ng0Iut18AJcyYCafBhNgv6Cs9GNnArrxk3Er2QYDMXPgtAmfEKC9HX1Co3dbm-bOOhhRzI_ldfGihzGaN_f1tPh5-eXHxbfy-vvXq4vz61LXDU0lJ0JUmmrBW2AkV1EJaVpKNJMGetPWogchCQDXmncaOGOyhUpAWxPNJTstPq---7mdTKdNnh1GtQ92grAoD1Ydd5wd1NYfFK9rQptbg_f3BsH_mk1MaufnkOeIitK8XIkJYY_UFkajrOt9NtOTjVqd16IRmGFKM3X2DyqfzkxWe2d6m_-PBB-eCAYDYxqiH-dkvYvHIF1BHXyMwfQPExKsbpOj1uSonBx1lxy1ZNG7p7t5kPyNSgbYCsTcyskIj7P_x_YPuZHRlw</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Chen, Bihong T.</creator><creator>Jin, Taihao</creator><creator>Patel, Sunita K.</creator><creator>Ye, Ningrong</creator><creator>Ma, Huiyan</creator><creator>Wong, Chi Wah</creator><creator>Rockne, Russell C.</creator><creator>Root, James C.</creator><creator>Saykin, Andrew J.</creator><creator>Ahles, Tim A.</creator><creator>Holodny, Andrei I.</creator><creator>Prakash, Neal</creator><creator>Mortimer, Joanne</creator><creator>Waisman, James</creator><creator>Yuan, Yuan</creator><creator>Li, Daneng</creator><creator>Sedrak, Mina S.</creator><creator>Vazquez, Jessica</creator><creator>Katheria, Vani</creator><creator>Dale, William</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3127-0711</orcidid></search><sort><creationdate>20190701</creationdate><title>Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study</title><author>Chen, Bihong T. ; Jin, Taihao ; Patel, Sunita K. ; Ye, Ningrong ; Ma, Huiyan ; Wong, Chi Wah ; Rockne, Russell C. ; Root, James C. ; Saykin, Andrew J. ; Ahles, Tim A. ; Holodny, Andrei I. ; Prakash, Neal ; Mortimer, Joanne ; Waisman, James ; Yuan, Yuan ; Li, Daneng ; Sedrak, Mina S. ; Vazquez, Jessica ; Katheria, Vani ; Dale, William</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-61884c2c86ba312c88489eb21c39eafeb58fa891aa6cc6dca6339ba48ab51c693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adjuvant treatment</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain</topic><topic>Brain mapping</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant - adverse effects</topic><topic>Chemotherapy, Adjuvant - methods</topic><topic>Clinical Trial</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Computed tomography</topic><topic>Cortex (parietal)</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>Health Care Surveys</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging</topic><topic>Measuring techniques</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Middle aged women</topic><topic>Neuroimaging</topic><topic>Neuroimaging - methods</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Pilot Projects</topic><topic>Psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Bihong T.</creatorcontrib><creatorcontrib>Jin, Taihao</creatorcontrib><creatorcontrib>Patel, Sunita K.</creatorcontrib><creatorcontrib>Ye, Ningrong</creatorcontrib><creatorcontrib>Ma, Huiyan</creatorcontrib><creatorcontrib>Wong, Chi Wah</creatorcontrib><creatorcontrib>Rockne, Russell C.</creatorcontrib><creatorcontrib>Root, James C.</creatorcontrib><creatorcontrib>Saykin, Andrew J.</creatorcontrib><creatorcontrib>Ahles, Tim A.</creatorcontrib><creatorcontrib>Holodny, Andrei I.</creatorcontrib><creatorcontrib>Prakash, Neal</creatorcontrib><creatorcontrib>Mortimer, Joanne</creatorcontrib><creatorcontrib>Waisman, James</creatorcontrib><creatorcontrib>Yuan, Yuan</creatorcontrib><creatorcontrib>Li, Daneng</creatorcontrib><creatorcontrib>Sedrak, Mina S.</creatorcontrib><creatorcontrib>Vazquez, Jessica</creatorcontrib><creatorcontrib>Katheria, Vani</creatorcontrib><creatorcontrib>Dale, William</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Bihong T.</au><au>Jin, Taihao</au><au>Patel, Sunita K.</au><au>Ye, Ningrong</au><au>Ma, Huiyan</au><au>Wong, Chi Wah</au><au>Rockne, Russell C.</au><au>Root, James C.</au><au>Saykin, Andrew J.</au><au>Ahles, Tim A.</au><au>Holodny, Andrei I.</au><au>Prakash, Neal</au><au>Mortimer, Joanne</au><au>Waisman, James</au><au>Yuan, Yuan</au><au>Li, Daneng</au><au>Sedrak, Mina S.</au><au>Vazquez, Jessica</au><au>Katheria, Vani</au><au>Dale, William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study</atitle><jtitle>Breast cancer research and treatment</jtitle><stitle>Breast Cancer Res Treat</stitle><addtitle>Breast Cancer Res Treat</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>176</volume><issue>1</issue><spage>181</spage><epage>189</epage><pages>181-189</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><abstract>Purpose
Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer.
Methods
Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60–82 years) with stage I–III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Fourteen age- and sex-matched healthy controls (HC) underwent the same assessments at matched intervals. Three voxel-wise rs-fMRI parameters: amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity, were computed at each time point. The changes in rs-fMRI parameters from TP1 to TP2 for each group, the group differences in changes (the CT group vs. the HC group), and the group difference in the baseline rs-fMRI parameters were assessed. In addition, correlative analysis between the rs-fMRI parameters and neuropsychological testing scores was also performed.
Results
In the CT group, one brain region, which included parts of the bilateral subcallosal gyri and right anterior cingulate gyrus, displayed increased ALFF from TP1 to TP2 (cluster
p
-corrected = 0.024); another brain region in the left precuneus displayed decreased fALFF from TP1 to TP2 (cluster level
p
-corrected = 0.025). No significant changes in the rs-fMRI parameters from TP1 to TP2 were observed in the HC group. Although ALFF and fALFF alterations were observed only in the CT group, none of the between-group differences in rs-fMRI parameter changes reached statistical significance.
Conclusions
Our study results of ALFF and fALFF alterations in the chemotherapy-treated women suggest that adjuvant chemotherapy may affect intrinsic brain activity in older women with breast cancer.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30989462</pmid><doi>10.1007/s10549-019-05230-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3127-0711</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-6806 |
| ispartof | Breast cancer research and treatment, 2019-07, Vol.176 (1), p.181-189 |
| issn | 0167-6806 1573-7217 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6551279 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adjuvant treatment Age Factors Aged Aged, 80 and over Brain Brain mapping Breast cancer Breast Neoplasms - complications Breast Neoplasms - drug therapy Breast Neoplasms - epidemiology Cancer Cancer research Chemotherapy Chemotherapy, Adjuvant - adverse effects Chemotherapy, Adjuvant - methods Clinical Trial Cognition Cognitive ability Cognitive Dysfunction - diagnosis Cognitive Dysfunction - epidemiology Cognitive Dysfunction - etiology Computed tomography Cortex (parietal) Female Functional magnetic resonance imaging Health Care Surveys Humans Image Processing, Computer-Assisted Longitudinal Studies Magnetic Resonance Imaging Measuring techniques Medicine Medicine & Public Health Middle Aged Middle aged women Neuroimaging Neuroimaging - methods Oncology Oncology, Experimental Pilot Projects Psychology |
| title | Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T23%3A16%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intrinsic%20brain%20activity%20changes%20associated%20with%20adjuvant%20chemotherapy%20in%20older%20women%20with%20breast%20cancer:%20a%20pilot%20longitudinal%20study&rft.jtitle=Breast%20cancer%20research%20and%20treatment&rft.au=Chen,%20Bihong%20T.&rft.date=2019-07-01&rft.volume=176&rft.issue=1&rft.spage=181&rft.epage=189&rft.pages=181-189&rft.issn=0167-6806&rft.eissn=1573-7217&rft_id=info:doi/10.1007/s10549-019-05230-y&rft_dat=%3Cgale_pubme%3EA587803022%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2209790113&rft_id=info:pmid/30989462&rft_galeid=A587803022&rfr_iscdi=true |