Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7

The correct localization of Hedgehog effectors to the tip of primary cilia is critical for proper signal transduction. The conserved non-motile kinesin Kif7 defines a “cilium-tip compartment” by localizing to the distal ends of axonemal microtubules. How Kif7 recognizes microtubule ends remains unkn...

Ausführliche Beschreibung