Hunting for genes that shape human faces: Initial successes and challenges for the future
Structured There is ample evidence from heritability studies, genetic syndromes and experimental animal models that facial morphology is strongly influenced by genes. In this brief review, we present an up‐to‐date overview of the efforts to identify genes associated with the size and shape of human...
Gespeichert in:
| Veröffentlicht in: | Orthodontics & craniofacial research 2019-05, Vol.22 (S1), p.207-212 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 212 |
|---|---|
| container_issue | S1 |
| container_start_page | 207 |
| container_title | Orthodontics & craniofacial research |
| container_volume | 22 |
| creator | Weinberg, Seth M. Roosenboom, Jasmien Shaffer, John R. Shriver, Mark D. Wysocka, Joanna Claes, Peter |
| description | Structured
There is ample evidence from heritability studies, genetic syndromes and experimental animal models that facial morphology is strongly influenced by genes. In this brief review, we present an up‐to‐date overview of the efforts to identify genes associated with the size and shape of human facial features. We discuss recent methodological advances that have led to breakthroughs, but also the multitude of challenges facing the field. We offer perspective on possible applications of this line of research, particularly in the context of the precision genomics movement. |
| doi_str_mv | 10.1111/ocr.12268 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6550302</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2231951700</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4438-be40d94fda142906b5e78b7868333c943b22c19299717628c04d365d69e8fe203</originalsourceid><addsrcrecordid>eNp1kctKxDAUhoMo3he-gATc6GI0t6aNC0EGbyAIogtXIU1Pp5VOOiaN4tubcXRQwWySQz6-cw4_QnuUHNN0TnrrjyljslhBm1QSOpJc8NXlm2cbaCuEZ0IYSdQ62uCU5IJm-SZ6uo5uaN0E173HE3AQ8NCYAYfGzAA3cWocro2FcIpvXDu0psMh2lSHRBpXYduYrgM3SeVcMTSA6zhEDztorTZdgN2vexs9Xl48jK9Ht3dXN-Pz25EVghejEgSplKgrQwVTRJYZ5EWZF7LgnFsleMmYpYopldNcssISUXGZVVJBUQMjfBudLbyzWE6hsuAGbzo98-3U-Hfdm1b__nFtoyf9q5ZZRjhhSXD4JfD9S4Qw6GkbLHSdcdDHoBnjVGU0J_NeB3_Q5z56l9ZLFGOCFURliTpaUNb3IXiol8NQoueB6RSY_gwssfs_p1-S3wkl4GQBvLUdvP9v0nfj-4XyA65rnrY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2222428095</pqid></control><display><type>article</type><title>Hunting for genes that shape human faces: Initial successes and challenges for the future</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Weinberg, Seth M. ; Roosenboom, Jasmien ; Shaffer, John R. ; Shriver, Mark D. ; Wysocka, Joanna ; Claes, Peter</creator><creatorcontrib>Weinberg, Seth M. ; Roosenboom, Jasmien ; Shaffer, John R. ; Shriver, Mark D. ; Wysocka, Joanna ; Claes, Peter</creatorcontrib><description>Structured
There is ample evidence from heritability studies, genetic syndromes and experimental animal models that facial morphology is strongly influenced by genes. In this brief review, we present an up‐to‐date overview of the efforts to identify genes associated with the size and shape of human facial features. We discuss recent methodological advances that have led to breakthroughs, but also the multitude of challenges facing the field. We offer perspective on possible applications of this line of research, particularly in the context of the precision genomics movement.</description><identifier>ISSN: 1601-6335</identifier><identifier>EISSN: 1601-6343</identifier><identifier>DOI: 10.1111/ocr.12268</identifier><identifier>PMID: 31074157</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Animal models ; complex genetic traits ; Dentistry ; face shape ; Genome-Wide Association Study ; genome‐wide association studies ; Genomics ; Genotype ; genotype‐phenotype correlation ; Heritability ; Humans ; Hunting ; normal‐range variation ; Phenotype</subject><ispartof>Orthodontics & craniofacial research, 2019-05, Vol.22 (S1), p.207-212</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4438-be40d94fda142906b5e78b7868333c943b22c19299717628c04d365d69e8fe203</citedby><cites>FETCH-LOGICAL-c4438-be40d94fda142906b5e78b7868333c943b22c19299717628c04d365d69e8fe203</cites><orcidid>0000-0001-9467-4556</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Focr.12268$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Focr.12268$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31074157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weinberg, Seth M.</creatorcontrib><creatorcontrib>Roosenboom, Jasmien</creatorcontrib><creatorcontrib>Shaffer, John R.</creatorcontrib><creatorcontrib>Shriver, Mark D.</creatorcontrib><creatorcontrib>Wysocka, Joanna</creatorcontrib><creatorcontrib>Claes, Peter</creatorcontrib><title>Hunting for genes that shape human faces: Initial successes and challenges for the future</title><title>Orthodontics & craniofacial research</title><addtitle>Orthod Craniofac Res</addtitle><description>Structured
There is ample evidence from heritability studies, genetic syndromes and experimental animal models that facial morphology is strongly influenced by genes. In this brief review, we present an up‐to‐date overview of the efforts to identify genes associated with the size and shape of human facial features. We discuss recent methodological advances that have led to breakthroughs, but also the multitude of challenges facing the field. We offer perspective on possible applications of this line of research, particularly in the context of the precision genomics movement.</description><subject>Animal models</subject><subject>complex genetic traits</subject><subject>Dentistry</subject><subject>face shape</subject><subject>Genome-Wide Association Study</subject><subject>genome‐wide association studies</subject><subject>Genomics</subject><subject>Genotype</subject><subject>genotype‐phenotype correlation</subject><subject>Heritability</subject><subject>Humans</subject><subject>Hunting</subject><subject>normal‐range variation</subject><subject>Phenotype</subject><issn>1601-6335</issn><issn>1601-6343</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKxDAUhoMo3he-gATc6GI0t6aNC0EGbyAIogtXIU1Pp5VOOiaN4tubcXRQwWySQz6-cw4_QnuUHNN0TnrrjyljslhBm1QSOpJc8NXlm2cbaCuEZ0IYSdQ62uCU5IJm-SZ6uo5uaN0E173HE3AQ8NCYAYfGzAA3cWocro2FcIpvXDu0psMh2lSHRBpXYduYrgM3SeVcMTSA6zhEDztorTZdgN2vexs9Xl48jK9Ht3dXN-Pz25EVghejEgSplKgrQwVTRJYZ5EWZF7LgnFsleMmYpYopldNcssISUXGZVVJBUQMjfBudLbyzWE6hsuAGbzo98-3U-Hfdm1b__nFtoyf9q5ZZRjhhSXD4JfD9S4Qw6GkbLHSdcdDHoBnjVGU0J_NeB3_Q5z56l9ZLFGOCFURliTpaUNb3IXiol8NQoueB6RSY_gwssfs_p1-S3wkl4GQBvLUdvP9v0nfj-4XyA65rnrY</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Weinberg, Seth M.</creator><creator>Roosenboom, Jasmien</creator><creator>Shaffer, John R.</creator><creator>Shriver, Mark D.</creator><creator>Wysocka, Joanna</creator><creator>Claes, Peter</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9467-4556</orcidid></search><sort><creationdate>201905</creationdate><title>Hunting for genes that shape human faces: Initial successes and challenges for the future</title><author>Weinberg, Seth M. ; Roosenboom, Jasmien ; Shaffer, John R. ; Shriver, Mark D. ; Wysocka, Joanna ; Claes, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-be40d94fda142906b5e78b7868333c943b22c19299717628c04d365d69e8fe203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal models</topic><topic>complex genetic traits</topic><topic>Dentistry</topic><topic>face shape</topic><topic>Genome-Wide Association Study</topic><topic>genome‐wide association studies</topic><topic>Genomics</topic><topic>Genotype</topic><topic>genotype‐phenotype correlation</topic><topic>Heritability</topic><topic>Humans</topic><topic>Hunting</topic><topic>normal‐range variation</topic><topic>Phenotype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weinberg, Seth M.</creatorcontrib><creatorcontrib>Roosenboom, Jasmien</creatorcontrib><creatorcontrib>Shaffer, John R.</creatorcontrib><creatorcontrib>Shriver, Mark D.</creatorcontrib><creatorcontrib>Wysocka, Joanna</creatorcontrib><creatorcontrib>Claes, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Orthodontics & craniofacial research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weinberg, Seth M.</au><au>Roosenboom, Jasmien</au><au>Shaffer, John R.</au><au>Shriver, Mark D.</au><au>Wysocka, Joanna</au><au>Claes, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hunting for genes that shape human faces: Initial successes and challenges for the future</atitle><jtitle>Orthodontics & craniofacial research</jtitle><addtitle>Orthod Craniofac Res</addtitle><date>2019-05</date><risdate>2019</risdate><volume>22</volume><issue>S1</issue><spage>207</spage><epage>212</epage><pages>207-212</pages><issn>1601-6335</issn><eissn>1601-6343</eissn><abstract>Structured
There is ample evidence from heritability studies, genetic syndromes and experimental animal models that facial morphology is strongly influenced by genes. In this brief review, we present an up‐to‐date overview of the efforts to identify genes associated with the size and shape of human facial features. We discuss recent methodological advances that have led to breakthroughs, but also the multitude of challenges facing the field. We offer perspective on possible applications of this line of research, particularly in the context of the precision genomics movement.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31074157</pmid><doi>10.1111/ocr.12268</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9467-4556</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1601-6335 |
| ispartof | Orthodontics & craniofacial research, 2019-05, Vol.22 (S1), p.207-212 |
| issn | 1601-6335 1601-6343 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6550302 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animal models complex genetic traits Dentistry face shape Genome-Wide Association Study genome‐wide association studies Genomics Genotype genotype‐phenotype correlation Heritability Humans Hunting normal‐range variation Phenotype |
| title | Hunting for genes that shape human faces: Initial successes and challenges for the future |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T01%3A27%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hunting%20for%20genes%20that%20shape%20human%20faces:%20Initial%20successes%20and%20challenges%20for%20the%20future&rft.jtitle=Orthodontics%20&%20craniofacial%20research&rft.au=Weinberg,%20Seth%20M.&rft.date=2019-05&rft.volume=22&rft.issue=S1&rft.spage=207&rft.epage=212&rft.pages=207-212&rft.issn=1601-6335&rft.eissn=1601-6343&rft_id=info:doi/10.1111/ocr.12268&rft_dat=%3Cproquest_pubme%3E2231951700%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2222428095&rft_id=info:pmid/31074157&rfr_iscdi=true |