Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response

Peritoneal malignant mesothelioma is a rare disease with a generally poor prognosis and poor response to chemotherapy. To improve survival there is a need for increased molecular understanding of the disease, including chemotherapy sensitivity and resistance. We here present an unusual case concerni...

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Veröffentlicht in:	Cold Spring Harbor molecular case studies 2019-04, Vol.5 (2), p.a003566
Hauptverfasser:	Lund-Andersen, Christin, Nakken, Sigve, Nygård, Ståle, Fromm, Bastian, Aasheim, Lars B, Davidson, Ben, Julsrud, Lars, Abrahamsen, Torveig W, Kristensen, Annette T, Dybdahl, Brit, Larsen, Stein G, Hovig, Eivind, Flatmark, Kjersti
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chemoresistance Chemotherapy Deactivation Deoxyribonucleic acid DNA DNA repair Female Gastric cancer Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Gene sequencing Genetic Variation Genomic analysis Genomics Homologous recombination Homology Humans Immune checkpoint inhibitors Lung Neoplasms - drug therapy Lung Neoplasms - genetics Medical prognosis Mesothelioma Mesothelioma - drug therapy Mesothelioma - genetics Mesothelioma, Malignant miRNA Palliative Care Pemetrexed - therapeutic use Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - genetics Peritoneum Platinum Platinum - therapeutic use Poly(ADP-ribose) polymerase Precision medicine PTEN protein Rare diseases Research Report Ribonucleic acid RNA Surgery TOR protein Transcription Treatment Outcome Young Adult
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