Adjuvant chemotherapy versus observation after radical cystectomy in patients with node-positive bladder cancer

This retrospective study compared adjuvant chemotherapy (AC) versus observation after radical cystectomy (RC) in patients with node-positive bladder cancer (pN+). Outcomes were reviewed in patients with pTanyN1-3M0 bladder cancer who underwent RC with or without AC between 1995 and 2017. Baseline ch...

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Veröffentlicht in:	Scientific reports 2019-06, Vol.9 (1), p.8305-8305, Article 8305
Hauptverfasser:	Pak, Sahyun, You, Dalsan, Jeong, In Gab, Song, Cheryn, Lee, Jae-Lyun, Hong, Bumsik, Hong, Jun Hyuk, Kim, Choung-Soo, Ahn, Hanjong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/99 692/4028/546 692/4028/67/589/1336 Aged Bladder cancer Cancer Chemotherapy Chemotherapy, Adjuvant Combined Modality Therapy Cystectomy Female Health risk assessment Humanities and Social Sciences Humans Kaplan-Meier Estimate Lymph nodes Lymph Nodes - pathology Male Middle Aged multidisciplinary Neoplasm Metastasis Postoperative Period Probability Proportional Hazards Models Prospective Studies Retrospective Studies Science Science (multidisciplinary) Survival Treatment Outcome Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - surgery
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Zusammenfassung:	This retrospective study compared adjuvant chemotherapy (AC) versus observation after radical cystectomy (RC) in patients with node-positive bladder cancer (pN+). Outcomes were reviewed in patients with pTanyN1-3M0 bladder cancer who underwent RC with or without AC between 1995 and 2017. Baseline characteristics between the two groups were controlled with inverse probability of treatment weighting (IPTW)-adjusted analyses. Of 281 enrolled patients, the 3-year IPTW-adjusted rates of overall survival was higher in the AC group than the RC group (46.4% vs. 33.7%, p = 0.024). AC was an independent predictor of overall survival (hazard ratio = 0.48; P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-44504-9