TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2 + semi-invariant TCRα that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites presented by MR1. MAIT cells are associated with immune control of bacterial and mycobacterial infections in murine mo...

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Veröffentlicht in:	Communications biology 2019-06, Vol.2 (1), p.203-203, Article 203
Hauptverfasser:	Wong, Emily B., Gold, Marielle C., Meermeier, Erin W., Xulu, Bongiwe Z., Khuzwayo, Sharon, Sullivan, Zuri A., Mahyari, Eisa, Rogers, Zoe, Kløverpris, Hénrik, Sharma, Prabhat K., Worley, Aneta H., Lalloo, Umesh, Baijnath, Prinita, Ambaram, Anish, Naidoo, Leon, Suleman, Moosa, Madansein, Rajhmun, McLaren, James E., Ladell, Kristin, Miners, Kelly L., Price, David A., Behar, Samuel M., Nielsen, Morten, Kasprowicz, Victoria O., Leslie, Alasdair, Bishai, William R., Ndung’u, Thumbi, Lewinsohn, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 631/250/1619/554/1775 631/250/347 692/699/255/1856 Alveoli Animal models Animals Antigens Biology Biomedical and Life Sciences Bronchi - microbiology Bronchoalveolar Lavage Fluid Bronchoscopy Bronchus CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - microbiology Histocompatibility Antigens Class I - immunology Humans Immune System Inflammation Intestines - immunology Life Sciences Lung - immunology Lung - microbiology Lymphocytes T Metabolites Mice Minor Histocompatibility Antigens - immunology Mucosa Mucosal-Associated Invariant T Cells - immunology Mucosal-Associated Invariant T Cells - microbiology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Oregon Phenotype Phenotypes Population Receptors, Antigen, T-Cell, alpha-beta - metabolism Riboflavin South Africa T cell receptors Tuberculosis Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - microbiology
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