The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer

Tumor angiogenesis and escape of immunosurveillance are two cancer hallmarks that are tightly linked and reciprocally regulated by paracrine signaling cues of cell constituents from both compartments. Formation and remodeling of new blood vessels in tumors is abnormal and facilitates immune evasion....

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Veröffentlicht in:	Seminars in cancer biology 2018-10, Vol.52 (Pt 2), p.107-116
Hauptverfasser:	Missiaen, Rindert, Mazzone, Massimiliano, Bergers, Gabriele
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - immunology Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals Antiangiogenic therapy Humans Immunosuppression Immunotherapy - methods Immunotherapy immune checkpoint inhibitors Innate and adaptive immune cells Metabolism Neoplasms - immunology Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - immunology T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Tumor hypoxia and acidosis Tumor Microenvironment - drug effects Tumor Microenvironment - immunology
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