The role of G-quadruplex structures of LIGS-generated aptamers R1.2 and R1.3 in IgM specific recognition

Exploiting a variant of SELEX called “Ligand-Guided Selection” (LI-GS), we recently identified two novel truncated G-rich aptamers, called R1.2 and R1.3, specific for membrane-bound IgM (mIgM), the hallmark of B cells. Herein, the conformational behaviour of these aptamers has been analysed by multi...

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Veröffentlicht in:	International journal of biological macromolecules 2019-07, Vol.133, p.839-849
Hauptverfasser:	Moccia, Federica, Platella, Chiara, Musumeci, Domenica, Batool, Sana, Zumrut, Hasan, Bradshaw, John, Mallikaratchy, Prabodhika, Montesarchio, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers B-cell lymphoma B-lymphocytes biomarkers biosensors buffers cations cellular microenvironment G-quadruplex immunoglobulin M Membrane-bound IgM neoplasm cells oligonucleotides potassium systematic evolution of ligands by exponential enrichment
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