Gasdermin D Protects from Melioidosis through Pyroptosis and Direct Killing of Bacteria

Gasdermin D (GSDMD) cleavage by caspase-1 or caspase-11 inflammasomes triggers pyroptosis, a lytic form of cell death protective against intracellular bacteria. In this study, we examine the role of GSDMD in a mouse model of melioidosis. mice were more susceptible than wild-type mice to intranasal i...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-06, Vol.202 (12), p.3468-3473
Hauptverfasser:	Wang, Jinyong, Deobald, Kelly, Re, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Burkholderia - physiology Burkholderia Infections - immunology Caspase 1 - genetics Caspase 1 - metabolism Caspases, Initiator - genetics Caspases, Initiator - metabolism Cells, Cultured Interleukin-18 - metabolism Interleukin-1beta - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Macrophages - immunology Macrophages - microbiology Melioidosis - immunology Mice Mice, Inbred C57BL Mice, Knockout Phosphate-Binding Proteins - genetics Phosphate-Binding Proteins - metabolism Pyroptosis
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