Structurally Diverse Histone Deacetylase Photoreactive Probes: Design, Synthesis, and Photolabeling Studies in Live Cells and Tissue

Histone deacetylase (HDAC) activity is modulated in vivo by post‐translational modifications and formation of multiprotein complexes. Novel chemical tools to study how these factors affect engagement of HDAC isoforms by HDAC inhibitors (HDACi) in cells and tissues are needed. In this study, a synthe...

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Veröffentlicht in:	ChemMedChem 2019-06, Vol.14 (11), p.1096-1107
Hauptverfasser:	Aboukhatwa, Shaimaa M., Hanigan, Thomas W., Taha, Taha Y., Neerasa, Jayaprakash, Ranjan, Rajeev, El‐Bastawissy, Eman E., Elkersh, Mohamed A., El‐Moselhy, Tarek F., Frasor, Jonna, Mahmud, Nadim, McLachlan, Alan, Petukhov, Pavel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell lines Cells, Cultured Drug Design Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacology HDAC protein Histone deacetylase Histone Deacetylase Inhibitors - chemical synthesis Histone Deacetylase Inhibitors - chemistry Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histones Humans inhibitors Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Isoforms Liver - diagnostic imaging Mice Mice, 129 Strain Optical Imaging Organic chemistry photoaffinity labeling Photoaffinity Labels - chemical synthesis Photoaffinity Labels - chemistry Photoaffinity Labels - pharmacology Probes target engagement tissue labeling Tissues
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