Neutral tumor evolution?

According to this traditional model, the selective advantage is conferred by a small set of driver mutations, but as the subclones that bear them successively expand, they also accumulate passenger mutations, which can be detected in sequencing experiments1. Genomes of individual tumors contain hund...

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Veröffentlicht in:	Nature genetics 2018-12, Vol.50 (12), p.1630-1633
Hauptverfasser:	Tarabichi, Maxime, Martincorena, Iñigo, Gerstung, Moritz, Leroi, Armand M., Markowetz, Florian, Spellman, Paul T., Morris, Quaid D., Lingjærde, Ole Christian, Wedge, David C., Van Loo, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/23 631/114 631/208/212 631/67 639/705 Agriculture Animal Genetics and Genomics Apoptosis Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell death Charitable foundations Computational biology Computer simulation Correspondence Drift Frequency distribution Gene Function Gene sequencing Genetic Drift Genetic variance Genomes Human Genetics Humans Medical genetics Medical research Molecular biology Mutation Neoplasms Neutral evolution Neutrality Selection, Genetic Simulation Tumors
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