Ras-ling with new therapeutic targets for metastasis

Successful cancer metastasis relies on the ability of cancer cells to survive independently of attachment to the extracellular matrix (ECM) and to overcome ECM-detachment-induced death programs. This can be accomplished through activating mutations in cellular oncogenes that subsequently lead to the...

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Veröffentlicht in:	Small GTPases 2019-07, Vol.10 (4), p.249-253
Hauptverfasser:	Mason, Joshua A., Schafer, Zachary T.
Format:	Artikel
Sprache:	eng
Schlagworte:	anoikis Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Commissioned Extracellular Matrix - metabolism Humans Immediate-Early Proteins - metabolism MAP Kinase Signaling System - drug effects metabolism metastasis Molecular Targeted Therapy Mutation Neoplasm Metastasis - drug therapy Neoplasm Metastasis - genetics PHLPP1 Protein-Serine-Threonine Kinases - metabolism Ras ras Proteins - antagonists & inhibitors ras Proteins - genetics ras Proteins - metabolism SGK1 Signal Transduction - drug effects
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