Somatic autophagy of axonal mitochondria in ischemic neurons

Mitophagy protects against ischemic neuronal injury by eliminating damaged mitochondria, but it is unclear how mitochondria in distal axons are cleared. We find that oxygen and glucose deprivation-reperfusion reduces mitochondrial content in both cell bodies and axons. Axonal mitochondria eliminatio...

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Veröffentlicht in:	The Journal of cell biology 2019-06, Vol.218 (6), p.1891-1907
Hauptverfasser:	Zheng, Yanrong, Zhang, Xiangnan, Wu, Xiaoli, Jiang, Lei, Ahsan, Anil, Ma, Shijia, Xiao, Ziyu, Han, Feng, Qin, Zheng-Hong, Hu, Weiwei, Chen, Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Anchoring Animals Autophagy Autophagy-Related Protein 7 - physiology Axons Axons - metabolism Axons - pathology Brain Ischemia - metabolism Brain Ischemia - pathology Cerebral Cortex - metabolism Cerebral Cortex - pathology Deprivation Dynein Injury prevention Ischemia Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Mitochondria Mitochondria - metabolism Mitochondria - pathology Mitophagy Motility Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Neurons - metabolism Neurons - pathology Phagocytosis Phagosomes Reperfusion Retrograde transport Ubiquitin-Protein Ligases - physiology
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