Rab5-dependent autophagosome closure by ESCRT

In the conserved autophagy pathway, autophagosomes (APs) engulf cellular components and deliver them to the lysosome for degradation. Before fusing with the lysosome, APs have to close via an unknown mechanism. We have previously shown that the endocytic Rab5-GTPase regulates AP closure. Therefore,...

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Veröffentlicht in:	The Journal of cell biology 2019-06, Vol.218 (6), p.1908-1927
Hauptverfasser:	Zhou, Fan, Wu, Zulin, Zhao, Mengzhu, Murtazina, Rakhilya, Cai, Juan, Zhang, Ao, Li, Rui, Sun, Dan, Li, Wenjing, Zhao, Lei, Li, Qunli, Zhu, Jing, Cong, Xiaoxia, Zhou, Yiting, Xie, Zhiping, Gyurkovska, Valeriya, Li, Liuju, Huang, Xiaoshuai, Xue, Yanhong, Chen, Liangyi, Xu, Hui, Xu, Haiqian, Liang, Yongheng, Segev, Nava
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adenosine triphosphatase Autophagosomes - physiology Autophagy Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism Cleavage Defects Depletion Endosomal Sorting Complexes Required for Transport - genetics Endosomal Sorting Complexes Required for Transport - metabolism Endosomes Guanosine triphosphatases Intracellular Membranes Localization Lysosomes - metabolism Phagocytosis Phagosomes Protein Transport rab5 GTP-Binding Proteins - genetics rab5 GTP-Binding Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism
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