Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4

Chromatin remodeling accompanies differentiation, however, its role in self-renewal is less well understood. We report that in Drosophila, the chromatin remodeler Kismet/CHD7/CHD8 limits intestinal stem cell (ISC) number and proliferation without affecting differentiation. Stem-cell-specific whole-g...

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Veröffentlicht in:	Developmental cell 2019-05, Vol.49 (4), p.556-573.e6
Hauptverfasser:	Gervais, Louis, van den Beek, Marius, Josserand, Manon, Sallé, Jérémy, Stefanutti, Marine, Perdigoto, Carolina N., Skorski, Patricia, Mazouni, Khallil, Marshall, Owen J., Brand, Andrea H., Schweisguth, François, Bardin, Allison J.
Format:	Artikel
Sprache:	eng
Schlagworte:	adult stem cells Animals Cbl Cell Differentiation - physiology Cell Proliferation - physiology Chromatin - metabolism Chromatin Assembly and Disassembly - physiology chromatin regulators DNA Helicases - metabolism DNA Helicases - physiology Drosophila melanogaster - metabolism Drosophila midgut Drosophila Proteins - metabolism Drosophila Proteins - physiology EGFR Epigenetic ErbB Receptors - metabolism Histone-Lysine N-Methyltransferase - metabolism Histone-Lysine N-Methyltransferase - physiology Histones - metabolism Homeodomain Proteins - metabolism Homeodomain Proteins - physiology Kismet/CHD7/CHD8 Life Sciences Proliferation control Receptors, Invertebrate Peptide - metabolism RNA Polymerase II - genetics RNA Polymerase II - metabolism Signal Transduction - physiology Stem Cells - metabolism tissue homeostasis Transcription Factors - metabolism Trr/MLL3/4
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