Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease

A disintegrine and metalloproteinase 10 (ADAM10) is implicated in synaptic function through its interaction with postsynaptic receptors and adhesion molecules. Here, we report that levels of active ADAM10 are increased in Huntington's disease (HD) mouse cortices and striata and in human postmor...

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Veröffentlicht in:	The Journal of clinical investigation 2019-06, Vol.129 (6), p.2390-2403
Hauptverfasser:	Vezzoli, Elena, Caron, Ilaria, Talpo, Francesca, Besusso, Dario, Conforti, Paola, Battaglia, Elisa, Sogne, Elisa, Falqui, Andrea, Petricca, Lara, Verani, Margherita, Martufi, Paola, Caricasole, Andrea, Bresciani, Alberto, Cecchetti, Ottavia, Rivetti di Val Cervo, Pia, Sancini, Giulio, Riess, Olaf, Nguyen, Hoa, Seipold, Lisa, Saftig, Paul, Biella, Gerardo, Cattaneo, Elena, Zuccato, Chiara
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM10 Protein - genetics ADAM10 Protein - metabolism Adult Aged Alzheimer's disease Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Animal models Animals Antigens, CD - genetics Antigens, CD - metabolism Autopsy Biomedical research Cadherins Cadherins - genetics Cadherins - metabolism Cell adhesion & migration Cognitive ability Cognitive Dysfunction - enzymology Cognitive Dysfunction - genetics Cognitive Dysfunction - pathology Disease Models, Animal Enzymes Female Gene expression Genotype & phenotype HEK293 Cells High definition television Humans Huntingtin Huntington Disease - enzymology Huntington Disease - genetics Huntington Disease - pathology Huntington's disease Huntingtons disease Hyperactivity Localization Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice, Transgenic Middle Aged N-Cadherin Neostriatum Neurons Peptides Phenotypes Polyglutamine Post-Synaptic Density - enzymology Post-Synaptic Density - genetics Post-Synaptic Density - pathology Proteins Proteolysis Receptor mechanisms Rodents Spiny neurons Synapses Transgenic animals Trinucleotide repeat diseases
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