Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm

RATIONALE:Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically increases with advancing age in men. However, the molecular mechanisms by which aging predisposes individuals to AAAs re...

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Veröffentlicht in:	Circulation research 2016-10, Vol.119 (10), p.1076-1088
Hauptverfasser:	Chen, Hou-Zao, Wang, Fang, Gao, Peng, Pei, Jian-Fei, Liu, Yue, Xu, Ting-Ting, Tang, Xiaoqiang, Fu, Wen-Yan, Lu, Jie, Yan, Yun-Fei, Wang, Xiao-Man, Han, Lei, Zhang, Zhu-Qin, Zhang, Ran, Zou, Ming-Hui, Liu, De-Pei
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aneurysm, Ruptured - etiology Angiotensin II - toxicity Animals Aortic Aneurysm, Abdominal - chemically induced Aortic Aneurysm, Abdominal - enzymology Aortic Aneurysm, Abdominal - etiology Aortic Aneurysm, Abdominal - metabolism Aortitis - metabolism Aortitis - pathology Apolipoproteins E - deficiency Calcium Chloride - toxicity Chemokine CCL2 - biosynthesis Chemokine CCL2 - genetics Disease Models, Animal Gene Expression Regulation Humans Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology NF-kappa B - metabolism Sirtuin 1 - deficiency Sirtuin 1 - genetics Sirtuin 1 - physiology
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