The origin of exosomal miR-1246 in human cancer cells

miR-1246 is considered an oncomiR in various cancer types. However, the origin and biogenesis of miR-1246 remain controversial which often leads to misinterpretation of its detection and biological function, and inevitably masking its mechanisms of action. Using next generation small RNA sequencing,...

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Veröffentlicht in:	RNA biology 2019-06, Vol.16 (6), p.770-784
Hauptverfasser:	Xu, Yi-Fan, Hannafon, Bethany N., Khatri, Ujjwol, Gin, Amy, Ding, Wei-Qun
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma binding proteins biogenesis cancer Cell Line Cell Line, Tumor CRISPR-Cas systems Exosome exosomes Exosomes - genetics gene editing human diseases Humans mechanism of action microRNA MicroRNAs - chemistry MicroRNAs - genetics MicroRNAs - metabolism neoplasm cells Neoplasms - genetics Neoplasms - metabolism Nucleotide Motifs quantitative polymerase chain reaction Research Paper reverse transcriptase polymerase chain reaction ribonucleases RNA, Nuclear - metabolism RNU2-1 sequence analysis small interfering RNA small nuclear RNA spliceosomes
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