Structural basis for inhibition of a response regulator of σ S stability by a ClpXP antiadaptor

The stationary phase promoter specificity subunit σ (RpoS) is delivered to the ClpXP machinery for degradation dependent on the adaptor RssB. This adaptor-specific degradation of σ provides a major point for regulation and transcriptional reprogramming during the general stress response. RssB is an...

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Veröffentlicht in:	Genes & development 2019-06, Vol.33 (11-12), p.718-732
Hauptverfasser:	Dorich, Victoria, Brugger, Christiane, Tripathi, Arti, Hoskins, Joel R, Tong, Song, Suhanovsky, Margaret M, Sastry, Amita, Wickner, Sue, Gottesman, Susan, Deaconescu, Alexandra M
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - metabolism Crystallography, X-Ray DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Escherichia coli Proteins - antagonists & inhibitors Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Models, Molecular Protein Conformation Protein Conformation, alpha-Helical Protein Domains Protein Stability Research Paper Sigma Factor - chemistry Sigma Factor - metabolism Transcription Factors - antagonists & inhibitors Transcription Factors - chemistry Transcription Factors - metabolism
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