CTLA-4 Protects against Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice

Vascular inflammation via T-cell-mediated immune responses has been shown to be critically involved in the pathogenesis of abdominal aortic aneurysm (AAA). T-cell coinhibitory molecule cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) is known to act as a potent negative regulator of immune respo...

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Veröffentlicht in:	Scientific reports 2019-05, Vol.9 (1), p.8065, Article 8065
Hauptverfasser:	Amin, Hilman Zulkifli, Sasaki, Naoto, Yamashita, Tomoya, Mizoguchi, Taiji, Hayashi, Tomohiro, Emoto, Takuo, Matsumoto, Takuya, Yoshida, Naofumi, Tabata, Tokiko, Horibe, Sayo, Kawauchi, Shoji, Rikitake, Yoshiyuki, Hirata, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 13/51 631/250/256 64/110 692/4019/592/75/593/1287 Aneurysms Angiotensin Angiotensin II Angiotensin II - toxicity Animals Aorta, Abdominal - drug effects Aorta, Abdominal - immunology Aorta, Abdominal - pathology Aortic Aneurysm, Abdominal - chemically induced Aortic Aneurysm, Abdominal - diagnosis Aortic Aneurysm, Abdominal - immunology Aortic Aneurysm, Abdominal - pathology Aortic aneurysms Aortic Rupture - chemically induced Aortic Rupture - immunology Aortic Rupture - pathology Apolipoprotein E Atherosclerosis - complications Atherosclerosis - immunology CD11c antigen CD4 antigen CD80 antigen CD86 antigen Cholesterol Costimulator CTLA-4 Antigen - genetics CTLA-4 Antigen - immunology CTLA-4 Antigen - metabolism CTLA-4 protein Cytotoxicity Dendritic cells Diet, Atherogenic - adverse effects Disease Models, Animal Effector cells High cholesterol diet Humanities and Social Sciences Humans Immune response (cell-mediated) Lymphocytes Lymphocytes T Lymphoid tissue Macrophages Male Mice Mice, Knockout, ApoE Mortality multidisciplinary Rupture Science Science (multidisciplinary) Severity of Illness Index T-Lymphocytes - immunology T-Lymphocytes - metabolism Therapeutic applications
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