Characterisation of Deubiquitylating Enzymes in the Cellular Response to High-LET Ionizing Radiation and Complex DNA Damage

Ionizing radiation, particular high-linear energy transfer (LET) radiation, can induce complex DNA damage (CDD) wherein 2 or more DNA lesions are induced in close proximity, which contributes significantly to the cell killing effects. However, knowledge of the enzymes and mechanisms involved in coor...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2019-07, Vol.104 (3), p.656-665
Hauptverfasser:	Carter, Rachel J., Nickson, Catherine M., Thompson, James M., Kacperek, Andrzej, Hill, Mark A., Parsons, Jason L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha Particles Carcinoma, Squamous Cell Cell Cycle Checkpoints Cell Line, Tumor Cell Survival DNA Damage DNA Repair HeLa Cells Humans Linear Energy Transfer Oropharyngeal Neoplasms Phthalazines - pharmacology Piperazines - pharmacology Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors Poly (ADP-Ribose) Polymerase-1 - genetics Poly (ADP-Ribose) Polymerase-1 - metabolism Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Proto-Oncogene Proteins - deficiency Protons Radiation Tolerance Radiation, Ionizing RNA, Small Interfering Ubiquitin Thiolesterase - deficiency
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!