Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression
Ursolic acid (UA) is a pentacyclic triterpene which is found in common herbs and medicinal plants that are reputed for a variety of pharmacological effects. Both as an active principle of these plants and as a nutraceutical ingredient, the pharmacology of UA in the CNS and other organs and systems h...
Gespeichert in:
| Veröffentlicht in: | Oxidative medicine and cellular longevity 2019-01, Vol.2019 (2019), p.1-18 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 18 |
|---|---|
| container_issue | 2019 |
| container_start_page | 1 |
| container_title | Oxidative medicine and cellular longevity |
| container_volume | 2019 |
| creator | Habtemariam, Solomon |
| description | Ursolic acid (UA) is a pentacyclic triterpene which is found in common herbs and medicinal plants that are reputed for a variety of pharmacological effects. Both as an active principle of these plants and as a nutraceutical ingredient, the pharmacology of UA in the CNS and other organs and systems has been extensively reported in recent years. In this communication, the antioxidant and anti-inflammatory axis of UA’s pharmacology is appraised for its therapeutic potential in some common CNS disorders. Classic examples include the traumatic brain injury (TBI), cerebral ischemia, cognition deficit, anxiety, and depression. The pharmacological efficacy for UA is demonstrated through the therapeutic principle of one drug→multitargets→one/many disease(s). Both specific enzymes and receptor targets along with diverse pharmacological effects associated with oxidative stress and inflammatory signalling are scrutinised. |
| doi_str_mv | 10.1155/2019/8512048 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6541953</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A613716082</galeid><sourcerecordid>A613716082</sourcerecordid><originalsourceid>FETCH-LOGICAL-c565t-5eaf77c82b1373fbf9840d80d707dcff825231497d020b0145e4dc3165f7f1793</originalsourceid><addsrcrecordid>eNqNkktvEzEUhUcIREthxxpZYoPUhPo5DxZIacojUoENXVse-zpxNGMHewaaX8TfxGlCKKxY-fX53Ht0T1E8J_g1IUJcUEyai1oQinn9oDglDadT3DT84XGP8UnxJKU1xiWjnDwuThihlHFanRY_Z35w4dYZ5QekvEG789R526m-V0OIW_QJ9Ep5l_qEgkWfYYxhE8MAOn_0qN2im5hC5zSaaWfeoJkxEVJyfokuo3IeLfx6jNsJmkOENqoOLZJeQe9UvgpL7-5krsA67YZJrn_rYMj4rpkr2NxpBf-0eGRVl-DZYT0rbt6_-zr_OL3-8mExn11PtSjFMBWgbFXpmraEVcy2tqk5NjU2Fa6MtramgjLCm8pgiltMuABuNCOlsJUlVcPOird73c3Y9mA0-CG3LDfR9SpuZVBO_v3i3Uouw3dZCk4awbLAq4NADN9GSIPsXdLQdcpDGJOklIsyz4rgjL78B12HMfpsL1MM51E196ml6kDmyYRcV-9E5azMLkmJa5qpyZ7SMaQUwR5bJljuciJ3OZGHnGT8xX2bR_h3MDJwvgdWzhv1w_2nHGQGrPpDUywqxtgvX5bP1A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2230241910</pqid></control><display><type>article</type><title>Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Habtemariam, Solomon</creator><contributor>Andrade, José P. ; José P Andrade</contributor><creatorcontrib>Habtemariam, Solomon ; Andrade, José P. ; José P Andrade</creatorcontrib><description>Ursolic acid (UA) is a pentacyclic triterpene which is found in common herbs and medicinal plants that are reputed for a variety of pharmacological effects. Both as an active principle of these plants and as a nutraceutical ingredient, the pharmacology of UA in the CNS and other organs and systems has been extensively reported in recent years. In this communication, the antioxidant and anti-inflammatory axis of UA’s pharmacology is appraised for its therapeutic potential in some common CNS disorders. Classic examples include the traumatic brain injury (TBI), cerebral ischemia, cognition deficit, anxiety, and depression. The pharmacological efficacy for UA is demonstrated through the therapeutic principle of one drug→multitargets→one/many disease(s). Both specific enzymes and receptor targets along with diverse pharmacological effects associated with oxidative stress and inflammatory signalling are scrutinised.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2019/8512048</identifier><identifier>PMID: 31223427</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acids ; Animal cognition ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Anti-inflammatory diet ; Anti-inflammatory drugs ; Antioxidants ; Antioxidants - metabolism ; Anxiety ; Anxiety - drug therapy ; Arthritis ; Brain ; Brain Ischemia - drug therapy ; Brain research ; Cerebral ischemia ; Cognitive Dysfunction - drug therapy ; Depression - drug therapy ; Depression, Mental ; Functional foods ; Humans ; Inflammation ; Injuries ; Ischemia ; Medicinal plants ; Medicine, Botanic ; Medicine, Herbal ; Metabolism ; Metabolites ; Natural products ; Neurogenesis ; Pharmacology ; Review ; Signal transduction ; Spinal cord injuries ; Traumatic brain injury ; Triterpenes - pharmacology ; Triterpenes - therapeutic use ; Ursolic Acid</subject><ispartof>Oxidative medicine and cellular longevity, 2019-01, Vol.2019 (2019), p.1-18</ispartof><rights>Copyright © 2019 Solomon Habtemariam.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Solomon Habtemariam. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Solomon Habtemariam. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-5eaf77c82b1373fbf9840d80d707dcff825231497d020b0145e4dc3165f7f1793</citedby><cites>FETCH-LOGICAL-c565t-5eaf77c82b1373fbf9840d80d707dcff825231497d020b0145e4dc3165f7f1793</cites><orcidid>0000-0001-6743-2244</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541953/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541953/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31223427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Andrade, José P.</contributor><contributor>José P Andrade</contributor><creatorcontrib>Habtemariam, Solomon</creatorcontrib><title>Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Ursolic acid (UA) is a pentacyclic triterpene which is found in common herbs and medicinal plants that are reputed for a variety of pharmacological effects. Both as an active principle of these plants and as a nutraceutical ingredient, the pharmacology of UA in the CNS and other organs and systems has been extensively reported in recent years. In this communication, the antioxidant and anti-inflammatory axis of UA’s pharmacology is appraised for its therapeutic potential in some common CNS disorders. Classic examples include the traumatic brain injury (TBI), cerebral ischemia, cognition deficit, anxiety, and depression. The pharmacological efficacy for UA is demonstrated through the therapeutic principle of one drug→multitargets→one/many disease(s). Both specific enzymes and receptor targets along with diverse pharmacological effects associated with oxidative stress and inflammatory signalling are scrutinised.</description><subject>Acids</subject><subject>Animal cognition</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Anti-inflammatory diet</subject><subject>Anti-inflammatory drugs</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Anxiety</subject><subject>Anxiety - drug therapy</subject><subject>Arthritis</subject><subject>Brain</subject><subject>Brain Ischemia - drug therapy</subject><subject>Brain research</subject><subject>Cerebral ischemia</subject><subject>Cognitive Dysfunction - drug therapy</subject><subject>Depression - drug therapy</subject><subject>Depression, Mental</subject><subject>Functional foods</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Injuries</subject><subject>Ischemia</subject><subject>Medicinal plants</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Natural products</subject><subject>Neurogenesis</subject><subject>Pharmacology</subject><subject>Review</subject><subject>Signal transduction</subject><subject>Spinal cord injuries</subject><subject>Traumatic brain injury</subject><subject>Triterpenes - pharmacology</subject><subject>Triterpenes - therapeutic use</subject><subject>Ursolic Acid</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkktvEzEUhUcIREthxxpZYoPUhPo5DxZIacojUoENXVse-zpxNGMHewaaX8TfxGlCKKxY-fX53Ht0T1E8J_g1IUJcUEyai1oQinn9oDglDadT3DT84XGP8UnxJKU1xiWjnDwuThihlHFanRY_Z35w4dYZ5QekvEG789R526m-V0OIW_QJ9Ep5l_qEgkWfYYxhE8MAOn_0qN2im5hC5zSaaWfeoJkxEVJyfokuo3IeLfx6jNsJmkOENqoOLZJeQe9UvgpL7-5krsA67YZJrn_rYMj4rpkr2NxpBf-0eGRVl-DZYT0rbt6_-zr_OL3-8mExn11PtSjFMBWgbFXpmraEVcy2tqk5NjU2Fa6MtramgjLCm8pgiltMuABuNCOlsJUlVcPOird73c3Y9mA0-CG3LDfR9SpuZVBO_v3i3Uouw3dZCk4awbLAq4NADN9GSIPsXdLQdcpDGJOklIsyz4rgjL78B12HMfpsL1MM51E196ml6kDmyYRcV-9E5azMLkmJa5qpyZ7SMaQUwR5bJljuciJ3OZGHnGT8xX2bR_h3MDJwvgdWzhv1w_2nHGQGrPpDUywqxtgvX5bP1A</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Habtemariam, Solomon</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6743-2244</orcidid></search><sort><creationdate>20190101</creationdate><title>Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression</title><author>Habtemariam, Solomon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-5eaf77c82b1373fbf9840d80d707dcff825231497d020b0145e4dc3165f7f1793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acids</topic><topic>Animal cognition</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Anti-inflammatory diet</topic><topic>Anti-inflammatory drugs</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Anxiety</topic><topic>Anxiety - drug therapy</topic><topic>Arthritis</topic><topic>Brain</topic><topic>Brain Ischemia - drug therapy</topic><topic>Brain research</topic><topic>Cerebral ischemia</topic><topic>Cognitive Dysfunction - drug therapy</topic><topic>Depression - drug therapy</topic><topic>Depression, Mental</topic><topic>Functional foods</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Injuries</topic><topic>Ischemia</topic><topic>Medicinal plants</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Natural products</topic><topic>Neurogenesis</topic><topic>Pharmacology</topic><topic>Review</topic><topic>Signal transduction</topic><topic>Spinal cord injuries</topic><topic>Traumatic brain injury</topic><topic>Triterpenes - pharmacology</topic><topic>Triterpenes - therapeutic use</topic><topic>Ursolic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Habtemariam, Solomon</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Habtemariam, Solomon</au><au>Andrade, José P.</au><au>José P Andrade</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>18</epage><pages>1-18</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Ursolic acid (UA) is a pentacyclic triterpene which is found in common herbs and medicinal plants that are reputed for a variety of pharmacological effects. Both as an active principle of these plants and as a nutraceutical ingredient, the pharmacology of UA in the CNS and other organs and systems has been extensively reported in recent years. In this communication, the antioxidant and anti-inflammatory axis of UA’s pharmacology is appraised for its therapeutic potential in some common CNS disorders. Classic examples include the traumatic brain injury (TBI), cerebral ischemia, cognition deficit, anxiety, and depression. The pharmacological efficacy for UA is demonstrated through the therapeutic principle of one drug→multitargets→one/many disease(s). Both specific enzymes and receptor targets along with diverse pharmacological effects associated with oxidative stress and inflammatory signalling are scrutinised.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31223427</pmid><doi>10.1155/2019/8512048</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0001-6743-2244</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1942-0900 |
| ispartof | Oxidative medicine and cellular longevity, 2019-01, Vol.2019 (2019), p.1-18 |
| issn | 1942-0900 1942-0994 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6541953 |
| source | MEDLINE; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acids Animal cognition Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Anti-inflammatory diet Anti-inflammatory drugs Antioxidants Antioxidants - metabolism Anxiety Anxiety - drug therapy Arthritis Brain Brain Ischemia - drug therapy Brain research Cerebral ischemia Cognitive Dysfunction - drug therapy Depression - drug therapy Depression, Mental Functional foods Humans Inflammation Injuries Ischemia Medicinal plants Medicine, Botanic Medicine, Herbal Metabolism Metabolites Natural products Neurogenesis Pharmacology Review Signal transduction Spinal cord injuries Traumatic brain injury Triterpenes - pharmacology Triterpenes - therapeutic use Ursolic Acid |
| title | Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T12%3A11%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antioxidant%20and%20Anti-inflammatory%20Mechanisms%20of%20Neuroprotection%20by%20Ursolic%20Acid:%20Addressing%20Brain%20Injury,%20Cerebral%20Ischemia,%20Cognition%20Deficit,%20Anxiety,%20and%20Depression&rft.jtitle=Oxidative%20medicine%20and%20cellular%20longevity&rft.au=Habtemariam,%20Solomon&rft.date=2019-01-01&rft.volume=2019&rft.issue=2019&rft.spage=1&rft.epage=18&rft.pages=1-18&rft.issn=1942-0900&rft.eissn=1942-0994&rft_id=info:doi/10.1155/2019/8512048&rft_dat=%3Cgale_pubme%3EA613716082%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2230241910&rft_id=info:pmid/31223427&rft_galeid=A613716082&rfr_iscdi=true |