Biomarker Effects in Carassius auratus Exposure to Ofloxacin, Sulfamethoxazole and Ibuprofen
Ofloxacin, sulfamethoxazole and ibuprofen are three commonly used drugs which can be detected in aquatic environments. To assess their ecotoxicity, the effects of these three pharmaceuticals and their mixture on AChE (acetylcholinesterase) activity in the brain, and EROD (7-ethoxyresorufin-O-deethyl...
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| description | Ofloxacin, sulfamethoxazole and ibuprofen are three commonly used drugs which can be detected in aquatic environments. To assess their ecotoxicity, the effects of these three pharmaceuticals and their mixture on AChE (acetylcholinesterase) activity in the brain, and EROD (7-ethoxyresorufin-O-deethylase) and SOD (superoxide dismutase) activities in the liver of the freshwater crucian carp
were tested after exposure for 1, 2, 4 and 7 days. The results showed that treatments with 0.002⁻0.01 mg/L ofloxacin and 0.0008⁻0.004 mg/L sulfamethoxazole did not significantly change AChE, EROD and SOD activities. AChE activity was significantly inhibited in response to treatment with 0.05mg/L ofloxacin and 0.02mg/L sulfamethoxazole. All three biomarkers were induced significantly in treatments with ibuprofen and the mixture of the three pharmaceuticals at all the tested concentrations. The combined effects of ofloxacin, sulfamethoxazole and ibuprofen were compared with their isolated effects on the three biomarkers, and the results indicated that exposure to ibuprofen and the mixture at environmentally relevant concentrations could trigger adverse impacts on
. The hazard quotient (HQ) index also demonstrated a high risk for ibuprofen. Moreover, the present study showed that the effects of ofloxacin, sulfamethoxazole and ibuprofen might be additive on the physiological indices of
. |
| doi_str_mv | 10.3390/ijerph16091628 |
| format | Article |
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were tested after exposure for 1, 2, 4 and 7 days. The results showed that treatments with 0.002⁻0.01 mg/L ofloxacin and 0.0008⁻0.004 mg/L sulfamethoxazole did not significantly change AChE, EROD and SOD activities. AChE activity was significantly inhibited in response to treatment with 0.05mg/L ofloxacin and 0.02mg/L sulfamethoxazole. All three biomarkers were induced significantly in treatments with ibuprofen and the mixture of the three pharmaceuticals at all the tested concentrations. The combined effects of ofloxacin, sulfamethoxazole and ibuprofen were compared with their isolated effects on the three biomarkers, and the results indicated that exposure to ibuprofen and the mixture at environmentally relevant concentrations could trigger adverse impacts on
. The hazard quotient (HQ) index also demonstrated a high risk for ibuprofen. Moreover, the present study showed that the effects of ofloxacin, sulfamethoxazole and ibuprofen might be additive on the physiological indices of
.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph16091628</identifier><identifier>PMID: 31075982</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acetylcholinesterase ; Acetylcholinesterase - metabolism ; Analgesics ; Animals ; Anti-inflammatory agents ; Antibiotics ; Aquatic organisms ; Benzene ; Biomarkers ; Biomarkers - metabolism ; Brain research ; Carassius auratus ; Chemicals ; Consumer products ; Cosmetics ; Cytochrome P-450 CYP1A1 - metabolism ; Detergents ; Drug Interactions ; Enzymes ; Glutathione reductase ; Goldfish - metabolism ; Ibuprofen ; Ibuprofen - toxicity ; Inflammation ; Iodides ; Ionization ; Lipids ; Liver - drug effects ; Liver - metabolism ; NADP ; NADPH ; Nicotinamide ; Nonsteroidal anti-inflammatory drugs ; Ofloxacin ; Ofloxacin - toxicity ; Organic chemistry ; Organisms ; Pharmaceuticals ; Physiology ; Pollutants ; Proteins ; Quadrupoles ; Reductases ; Sulfamethoxazole ; Sulfamethoxazole - toxicity ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Surface water ; Toxicity ; Variance analysis ; Water Pollutants, Chemical - toxicity</subject><ispartof>International journal of environmental research and public health, 2019-05, Vol.16 (9), p.1628</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-a0b53f2687d551f4e00e82860ae7d9ff62cd3bde51311babda90f6e95d9410543</citedby><cites>FETCH-LOGICAL-c418t-a0b53f2687d551f4e00e82860ae7d9ff62cd3bde51311babda90f6e95d9410543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540135/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540135/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31075982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Xiaofan</creatorcontrib><creatorcontrib>Xu, Xiaoping</creatorcontrib><creatorcontrib>Wei, Xueyu</creatorcontrib><creatorcontrib>Wan, Jie</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><title>Biomarker Effects in Carassius auratus Exposure to Ofloxacin, Sulfamethoxazole and Ibuprofen</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Ofloxacin, sulfamethoxazole and ibuprofen are three commonly used drugs which can be detected in aquatic environments. To assess their ecotoxicity, the effects of these three pharmaceuticals and their mixture on AChE (acetylcholinesterase) activity in the brain, and EROD (7-ethoxyresorufin-O-deethylase) and SOD (superoxide dismutase) activities in the liver of the freshwater crucian carp
were tested after exposure for 1, 2, 4 and 7 days. The results showed that treatments with 0.002⁻0.01 mg/L ofloxacin and 0.0008⁻0.004 mg/L sulfamethoxazole did not significantly change AChE, EROD and SOD activities. AChE activity was significantly inhibited in response to treatment with 0.05mg/L ofloxacin and 0.02mg/L sulfamethoxazole. All three biomarkers were induced significantly in treatments with ibuprofen and the mixture of the three pharmaceuticals at all the tested concentrations. The combined effects of ofloxacin, sulfamethoxazole and ibuprofen were compared with their isolated effects on the three biomarkers, and the results indicated that exposure to ibuprofen and the mixture at environmentally relevant concentrations could trigger adverse impacts on
. The hazard quotient (HQ) index also demonstrated a high risk for ibuprofen. Moreover, the present study showed that the effects of ofloxacin, sulfamethoxazole and ibuprofen might be additive on the physiological indices of
.</description><subject>Acetylcholinesterase</subject><subject>Acetylcholinesterase - metabolism</subject><subject>Analgesics</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Antibiotics</subject><subject>Aquatic organisms</subject><subject>Benzene</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Brain research</subject><subject>Carassius auratus</subject><subject>Chemicals</subject><subject>Consumer products</subject><subject>Cosmetics</subject><subject>Cytochrome P-450 CYP1A1 - metabolism</subject><subject>Detergents</subject><subject>Drug Interactions</subject><subject>Enzymes</subject><subject>Glutathione reductase</subject><subject>Goldfish - metabolism</subject><subject>Ibuprofen</subject><subject>Ibuprofen - toxicity</subject><subject>Inflammation</subject><subject>Iodides</subject><subject>Ionization</subject><subject>Lipids</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>NADP</subject><subject>NADPH</subject><subject>Nicotinamide</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Ofloxacin</subject><subject>Ofloxacin - toxicity</subject><subject>Organic chemistry</subject><subject>Organisms</subject><subject>Pharmaceuticals</subject><subject>Physiology</subject><subject>Pollutants</subject><subject>Proteins</subject><subject>Quadrupoles</subject><subject>Reductases</subject><subject>Sulfamethoxazole</subject><subject>Sulfamethoxazole - toxicity</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Surface water</subject><subject>Toxicity</subject><subject>Variance analysis</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVUU1PwzAMjRCI7ytHFIkrHU7zseaCBNP4kJB2AG5IUdo6rKNrStKiwa-naIDg9Cz7-fnZJuSIwYhzDWfVAkM7Zwo0U2m2QXaZUpAIBWzzT7xD9mJcAPBMKL1NdjiDsdRZukueLiu_tOEFA506h0UXadXQiQ02xqqP1PbBdgNOV62PfUDaeTpztV_ZompO6X1fO7vEbj4kPnyN1DYlvc37NniHzQHZcraOePiN--TxavowuUnuZte3k4u7pBAs6xILueQuVdm4lJI5gQCYpZkCi-NSO6fSouR5iZJxxnKbl1aDU6hlqQUDKfg-OV_rtn2-xLLApgu2Nm2ohtXejbeV-V9pqrl59m9GSQGMy0Hg5Fsg-NceY2cWvg_N4NmkPNUwVkJmA2u0ZhXBxxjQ_U5gYL6-Yf5_Y2g4_uvrl_5zfv4Ja8uI9Q</recordid><startdate>20190509</startdate><enddate>20190509</enddate><creator>Yang, Xiaofan</creator><creator>Xu, Xiaoping</creator><creator>Wei, Xueyu</creator><creator>Wan, Jie</creator><creator>Zhang, Yu</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20190509</creationdate><title>Biomarker Effects in Carassius auratus Exposure to Ofloxacin, Sulfamethoxazole and Ibuprofen</title><author>Yang, Xiaofan ; Xu, Xiaoping ; Wei, Xueyu ; Wan, Jie ; Zhang, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-a0b53f2687d551f4e00e82860ae7d9ff62cd3bde51311babda90f6e95d9410543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetylcholinesterase</topic><topic>Acetylcholinesterase - metabolism</topic><topic>Analgesics</topic><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Antibiotics</topic><topic>Aquatic organisms</topic><topic>Benzene</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Brain research</topic><topic>Carassius auratus</topic><topic>Chemicals</topic><topic>Consumer products</topic><topic>Cosmetics</topic><topic>Cytochrome P-450 CYP1A1 - metabolism</topic><topic>Detergents</topic><topic>Drug Interactions</topic><topic>Enzymes</topic><topic>Glutathione reductase</topic><topic>Goldfish - metabolism</topic><topic>Ibuprofen</topic><topic>Ibuprofen - toxicity</topic><topic>Inflammation</topic><topic>Iodides</topic><topic>Ionization</topic><topic>Lipids</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>NADP</topic><topic>NADPH</topic><topic>Nicotinamide</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Ofloxacin</topic><topic>Ofloxacin - toxicity</topic><topic>Organic chemistry</topic><topic>Organisms</topic><topic>Pharmaceuticals</topic><topic>Physiology</topic><topic>Pollutants</topic><topic>Proteins</topic><topic>Quadrupoles</topic><topic>Reductases</topic><topic>Sulfamethoxazole</topic><topic>Sulfamethoxazole - toxicity</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Surface water</topic><topic>Toxicity</topic><topic>Variance analysis</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Xiaofan</creatorcontrib><creatorcontrib>Xu, Xiaoping</creatorcontrib><creatorcontrib>Wei, Xueyu</creatorcontrib><creatorcontrib>Wan, Jie</creatorcontrib><creatorcontrib>Zhang, Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Xiaofan</au><au>Xu, Xiaoping</au><au>Wei, Xueyu</au><au>Wan, Jie</au><au>Zhang, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarker Effects in Carassius auratus Exposure to Ofloxacin, Sulfamethoxazole and Ibuprofen</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2019-05-09</date><risdate>2019</risdate><volume>16</volume><issue>9</issue><spage>1628</spage><pages>1628-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Ofloxacin, sulfamethoxazole and ibuprofen are three commonly used drugs which can be detected in aquatic environments. To assess their ecotoxicity, the effects of these three pharmaceuticals and their mixture on AChE (acetylcholinesterase) activity in the brain, and EROD (7-ethoxyresorufin-O-deethylase) and SOD (superoxide dismutase) activities in the liver of the freshwater crucian carp
were tested after exposure for 1, 2, 4 and 7 days. The results showed that treatments with 0.002⁻0.01 mg/L ofloxacin and 0.0008⁻0.004 mg/L sulfamethoxazole did not significantly change AChE, EROD and SOD activities. AChE activity was significantly inhibited in response to treatment with 0.05mg/L ofloxacin and 0.02mg/L sulfamethoxazole. All three biomarkers were induced significantly in treatments with ibuprofen and the mixture of the three pharmaceuticals at all the tested concentrations. The combined effects of ofloxacin, sulfamethoxazole and ibuprofen were compared with their isolated effects on the three biomarkers, and the results indicated that exposure to ibuprofen and the mixture at environmentally relevant concentrations could trigger adverse impacts on
. The hazard quotient (HQ) index also demonstrated a high risk for ibuprofen. Moreover, the present study showed that the effects of ofloxacin, sulfamethoxazole and ibuprofen might be additive on the physiological indices of
.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31075982</pmid><doi>10.3390/ijerph16091628</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylcholinesterase Acetylcholinesterase - metabolism Analgesics Animals Anti-inflammatory agents Antibiotics Aquatic organisms Benzene Biomarkers Biomarkers - metabolism Brain research Carassius auratus Chemicals Consumer products Cosmetics Cytochrome P-450 CYP1A1 - metabolism Detergents Drug Interactions Enzymes Glutathione reductase Goldfish - metabolism Ibuprofen Ibuprofen - toxicity Inflammation Iodides Ionization Lipids Liver - drug effects Liver - metabolism NADP NADPH Nicotinamide Nonsteroidal anti-inflammatory drugs Ofloxacin Ofloxacin - toxicity Organic chemistry Organisms Pharmaceuticals Physiology Pollutants Proteins Quadrupoles Reductases Sulfamethoxazole Sulfamethoxazole - toxicity Superoxide dismutase Superoxide Dismutase - metabolism Surface water Toxicity Variance analysis Water Pollutants, Chemical - toxicity |
| title | Biomarker Effects in Carassius auratus Exposure to Ofloxacin, Sulfamethoxazole and Ibuprofen |
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