Relationship between the IL23R SNPs and Crohn's Disease Susceptibility and Phenotype in the Polish and Bosnian Populations: A Case-Control Study
It is suggested that IL-23/IL-17 axis and single nucleotide polymorphisms (SNPs) of may have crucial role in pathogenesis of Crohn's disease (CD). Thus, we sought to assess the SNPs contribution to susceptibility and phenotype of CD. We recruited 117 CD subjects and 117 controls from Poland and...
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| Veröffentlicht in: | International journal of environmental research and public health 2019-05, Vol.16 (9), p.1551 |
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| creator | Borecki, Krzysztof Zawada, Iwona Salkić, Nermin Nusret Karakiewicz, Beata Adler, Grażyna |
| description | It is suggested that IL-23/IL-17 axis and single nucleotide polymorphisms (SNPs) of
may have crucial role in pathogenesis of Crohn's disease (CD). Thus, we sought to assess the
SNPs contribution to susceptibility and phenotype of CD. We recruited 117 CD subjects and 117 controls from Poland and 30 CD subjects and 30 controls from Bosnia and Herzegovina (B&H). Two common
SNPs: rs1004819, rs7517847 were genotyped using TaqMan SNP assays. In the Polish population it was found that allele rs1004819: A increases the risk of CD, while allele rs7517847: A is protective against disease development. In Poles the co-carriage of two
risk genotypes was associated with increased risk of CD. A significantly increased risk of CD early onset was observed in Poles carrying at least one rs7517847: G allele. It was also found that
SNPs may be associated with structuring/penetrating CD behavior, as alleles rs1004819: A and rs7517847: G were significantly less frequent in patients without complications, from Poland and B&H, respectively. Allele rs1004819: A was also significantly more frequent in Poles with penetrating CD. These results confirm
SNPs contribution to CD susceptibility in the Polish population and suggest their impact on early age of onset and more severe disease course. |
| doi_str_mv | 10.3390/ijerph16091551 |
| format | Article |
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may have crucial role in pathogenesis of Crohn's disease (CD). Thus, we sought to assess the
SNPs contribution to susceptibility and phenotype of CD. We recruited 117 CD subjects and 117 controls from Poland and 30 CD subjects and 30 controls from Bosnia and Herzegovina (B&H). Two common
SNPs: rs1004819, rs7517847 were genotyped using TaqMan SNP assays. In the Polish population it was found that allele rs1004819: A increases the risk of CD, while allele rs7517847: A is protective against disease development. In Poles the co-carriage of two
risk genotypes was associated with increased risk of CD. A significantly increased risk of CD early onset was observed in Poles carrying at least one rs7517847: G allele. It was also found that
SNPs may be associated with structuring/penetrating CD behavior, as alleles rs1004819: A and rs7517847: G were significantly less frequent in patients without complications, from Poland and B&H, respectively. Allele rs1004819: A was also significantly more frequent in Poles with penetrating CD. These results confirm
SNPs contribution to CD susceptibility in the Polish population and suggest their impact on early age of onset and more severe disease course.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph16091551</identifier><identifier>PMID: 31052515</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Alleles ; Blood ; Bosnia and Herzegovina - epidemiology ; Case-Control Studies ; CD4 antigen ; Crohn Disease - epidemiology ; Crohn Disease - genetics ; Cytokines ; Deoxyribonucleic acid ; Digestive system ; DNA ; Female ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Helper cells ; Humans ; Inflammation ; Interleukin 17 ; Interleukin 21 ; Interleukin 22 ; Interleukin 23 ; Intestine ; Leukocytes ; Lymphocytes ; Lymphocytes T ; Male ; Middle Aged ; Optimization ; Peripheral blood ; Phenotype ; Phenotypes ; Poland - epidemiology ; Polymorphism, Single Nucleotide ; Population ; Population studies ; Receptors, Interleukin - genetics ; Single-nucleotide polymorphism ; Software ; Statistical analysis ; Studies</subject><ispartof>International journal of environmental research and public health, 2019-05, Vol.16 (9), p.1551</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-d62e149b312a783f0162e827a780db09f45100323f210f25bb18c3f02bfb1ab53</citedby><cites>FETCH-LOGICAL-c418t-d62e149b312a783f0162e827a780db09f45100323f210f25bb18c3f02bfb1ab53</cites><orcidid>0000-0002-5689-3771 ; 0000-0003-4727-9267 ; 0000-0001-8792-553X ; 0000-0001-6527-7287</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539781/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539781/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31052515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borecki, Krzysztof</creatorcontrib><creatorcontrib>Zawada, Iwona</creatorcontrib><creatorcontrib>Salkić, Nermin Nusret</creatorcontrib><creatorcontrib>Karakiewicz, Beata</creatorcontrib><creatorcontrib>Adler, Grażyna</creatorcontrib><title>Relationship between the IL23R SNPs and Crohn's Disease Susceptibility and Phenotype in the Polish and Bosnian Populations: A Case-Control Study</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>It is suggested that IL-23/IL-17 axis and single nucleotide polymorphisms (SNPs) of
may have crucial role in pathogenesis of Crohn's disease (CD). Thus, we sought to assess the
SNPs contribution to susceptibility and phenotype of CD. We recruited 117 CD subjects and 117 controls from Poland and 30 CD subjects and 30 controls from Bosnia and Herzegovina (B&H). Two common
SNPs: rs1004819, rs7517847 were genotyped using TaqMan SNP assays. In the Polish population it was found that allele rs1004819: A increases the risk of CD, while allele rs7517847: A is protective against disease development. In Poles the co-carriage of two
risk genotypes was associated with increased risk of CD. A significantly increased risk of CD early onset was observed in Poles carrying at least one rs7517847: G allele. It was also found that
SNPs may be associated with structuring/penetrating CD behavior, as alleles rs1004819: A and rs7517847: G were significantly less frequent in patients without complications, from Poland and B&H, respectively. Allele rs1004819: A was also significantly more frequent in Poles with penetrating CD. These results confirm
SNPs contribution to CD susceptibility in the Polish population and suggest their impact on early age of onset and more severe disease course.</description><subject>Adult</subject><subject>Alleles</subject><subject>Blood</subject><subject>Bosnia and Herzegovina - epidemiology</subject><subject>Case-Control Studies</subject><subject>CD4 antigen</subject><subject>Crohn Disease - epidemiology</subject><subject>Crohn Disease - genetics</subject><subject>Cytokines</subject><subject>Deoxyribonucleic acid</subject><subject>Digestive system</subject><subject>DNA</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Helper cells</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 17</subject><subject>Interleukin 21</subject><subject>Interleukin 22</subject><subject>Interleukin 23</subject><subject>Intestine</subject><subject>Leukocytes</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Optimization</subject><subject>Peripheral blood</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Poland - epidemiology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Population studies</subject><subject>Receptors, Interleukin - genetics</subject><subject>Single-nucleotide polymorphism</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Studies</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUtv1DAUhS0EoqWwZYkssYBNiq8d58ECqYRXpRGMOrC27OSGeJSxQ-yA5l_wkzGdoWpZ2b738_E9PoQ8BXYuRM1e2S3O0wAFq0FKuEdOoShYlhcM7t_an5BHIWwZE1Ve1A_JiQAmuQR5Sn5f4aij9S4MdqIG4y9ER-OA9HLFxRXdfF4Hql1Hm9kP7kWg72xAHZBultDiFK2xo437a2Q9oPNxPyG1B4m1H20YrntvfXBWu1SaluODr-kFbZJU1ngXZz_STVy6_WPyoNdjwCfH9Yx8-_D-a_MpW335eNlcrLI2hypmXcER8toI4LqsRM8gFSpepgPrDKv7XELyy0XPgfVcGgNVmzBuegPaSHFG3hx0p8XssGsxzaBHNc12p-e98tqqux1nB_Xd_1SFFHVZQRJ4eRSY_Y8FQ1Q7m75kHLVDvwTFOa95LhmrEvr8P3Trl9kle4oLXrNSsDJP1PmBamcfwoz9zTDA1N-w1d2w04Vnty3c4P_SFX8AeEKm3g</recordid><startdate>20190502</startdate><enddate>20190502</enddate><creator>Borecki, Krzysztof</creator><creator>Zawada, Iwona</creator><creator>Salkić, Nermin Nusret</creator><creator>Karakiewicz, Beata</creator><creator>Adler, Grażyna</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5689-3771</orcidid><orcidid>https://orcid.org/0000-0003-4727-9267</orcidid><orcidid>https://orcid.org/0000-0001-8792-553X</orcidid><orcidid>https://orcid.org/0000-0001-6527-7287</orcidid></search><sort><creationdate>20190502</creationdate><title>Relationship between the IL23R SNPs and Crohn's Disease Susceptibility and Phenotype in the Polish and Bosnian Populations: A Case-Control Study</title><author>Borecki, Krzysztof ; 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may have crucial role in pathogenesis of Crohn's disease (CD). Thus, we sought to assess the
SNPs contribution to susceptibility and phenotype of CD. We recruited 117 CD subjects and 117 controls from Poland and 30 CD subjects and 30 controls from Bosnia and Herzegovina (B&H). Two common
SNPs: rs1004819, rs7517847 were genotyped using TaqMan SNP assays. In the Polish population it was found that allele rs1004819: A increases the risk of CD, while allele rs7517847: A is protective against disease development. In Poles the co-carriage of two
risk genotypes was associated with increased risk of CD. A significantly increased risk of CD early onset was observed in Poles carrying at least one rs7517847: G allele. It was also found that
SNPs may be associated with structuring/penetrating CD behavior, as alleles rs1004819: A and rs7517847: G were significantly less frequent in patients without complications, from Poland and B&H, respectively. Allele rs1004819: A was also significantly more frequent in Poles with penetrating CD. These results confirm
SNPs contribution to CD susceptibility in the Polish population and suggest their impact on early age of onset and more severe disease course.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31052515</pmid><doi>10.3390/ijerph16091551</doi><orcidid>https://orcid.org/0000-0002-5689-3771</orcidid><orcidid>https://orcid.org/0000-0003-4727-9267</orcidid><orcidid>https://orcid.org/0000-0001-8792-553X</orcidid><orcidid>https://orcid.org/0000-0001-6527-7287</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alleles Blood Bosnia and Herzegovina - epidemiology Case-Control Studies CD4 antigen Crohn Disease - epidemiology Crohn Disease - genetics Cytokines Deoxyribonucleic acid Digestive system DNA Female Genetic Predisposition to Disease Genotype Genotype & phenotype Helper cells Humans Inflammation Interleukin 17 Interleukin 21 Interleukin 22 Interleukin 23 Intestine Leukocytes Lymphocytes Lymphocytes T Male Middle Aged Optimization Peripheral blood Phenotype Phenotypes Poland - epidemiology Polymorphism, Single Nucleotide Population Population studies Receptors, Interleukin - genetics Single-nucleotide polymorphism Software Statistical analysis Studies |
| title | Relationship between the IL23R SNPs and Crohn's Disease Susceptibility and Phenotype in the Polish and Bosnian Populations: A Case-Control Study |
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