CXCR4 Cardiac Specific Knockout Mice Develop a Progressive Cardiomyopathy

Activation of multiple pathways is associated with cardiac hypertrophy and heart failure. We previously published that CXCR4 negatively regulates β-adrenergic receptor (β-AR) signaling and ultimately limits β-adrenergic diastolic (Ca ) accumulation in cardiac myocytes. In isolated adult rat cardiac...

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Veröffentlicht in:	International journal of molecular sciences 2019-05, Vol.20 (9), p.2267
Hauptverfasser:	LaRocca, Thomas J, Altman, Perry, Jarrah, Andrew A, Gordon, Ron, Wang, Edward, Hadri, Lahouaria, Burke, Mark W, Haddad, Georges E, Hajjar, Roger J, Tarzami, Sima T
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Arteriosclerosis Atherosclerosis ATP synthase Atrial Natriuretic Factor - genetics Calcium Cardiac function Cardiomyocytes Cardiomyopathies - genetics Cardiomyopathies - physiopathology Cardiomyopathy Cardiovascular disease Cell adhesion & migration Channel gating Chemokine CXCL12 - genetics Chemokines Congestive heart failure CXCL12 protein CXCR4 protein Cytochrome Cytochrome-c oxidase Diabetes mellitus Disease Models, Animal Gene Expression Regulation - drug effects Heart - drug effects Heart - physiopathology Heart failure Heart Failure - genetics Heart Failure - physiopathology Human behavior Humans Hypercholesterolemia Hypertension Isoproterenol - administration & dosage Ligands Mice Mice, Knockout Microscopy Mitochondria Mitochondria, Heart - genetics Mitochondria, Heart - pathology Muscle contraction Myocardial infarction Myocytes, Cardiac - drug effects Myocytes, Cardiac - pathology NMR Nuclear magnetic resonance Receptors, Adrenergic, beta - genetics Receptors, CXCR4 - genetics Risk analysis Risk factors Signal Transduction - genetics Ventricle
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