The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation

Port wine stain (PWS) is a congenital vascular malformation involving human skin. Approximately 15-20% of children a facial PWS involving the ophthalmic (V1) trigeminal dermatome are at risk for Sturge Weber syndrome (SWS), a neurocutaneous disorder with vascular malformations in the cerebral cortex...

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Veröffentlicht in:	International journal of molecular sciences 2019-05, Vol.20 (9), p.2243
Hauptverfasser:	Nguyen, Vi, Hochman, Marcelo, Mihm, Jr, Martin C, Nelson, J Stuart, Tan, Wenbin
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activation Age Airway management Angiogenesis Inhibitors - therapeutic use Animals Anomalies Cell adhesion & migration Congenital defects Dermatitis Glaucoma Guanine Guanine nucleotide-binding protein Humans Infants Kinases Laser Therapy MAP kinase Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Mutation NMR Nuclear magnetic resonance Nucleotides Pathogenesis Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Port-Wine Stain - etiology Port-Wine Stain - therapy Protein kinase Proteins Review Skin Skin diseases Skin lesions Sturge-Weber Syndrome - etiology Sturge-Weber Syndrome - therapy Wine
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