Papillomavirus E2 protein is regulated by specific fibroblast growth factor receptors

The papillomavirus (PV) E2 protein activates transcription and replication by recruiting cellular proteins and the E1 DNA helicase to their binding sites in the viral genome. We recently demonstrated that phosphorylation of tyrosine 102 in the bovine papillomavirus (BPV-1) E2 protein restricts these...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2018-08, Vol.521, p.62-68
Hauptverfasser:	DeSmet, Marsha, Kanginakudru, Sriramana, Jose, Leny, Xie, Fang, Gilson, Timra, Androphy, Elliot J.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal viruses binding sites Deltapapillomavirus 4 DNA helicases DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism enzyme activity epithelial cells Fibroblast growth factor receptor fibroblast growth factor receptor 1 fibroblast growth factor receptor 2 fibroblast growth factor receptor 3 fibroblast growth factor receptor 4 genome HEK293 Cells Host Microbial Interactions Human papillomavirus 16 - physiology Humans Immunoprecipitation Papillomavirus E2 phosphorylation phenylalanine Phosphorylation Protein-Tyrosine Kinases proteins Receptor, Fibroblast Growth Factor, Type 1 - metabolism Receptor, Fibroblast Growth Factor, Type 2 - metabolism Receptor, Fibroblast Growth Factor, Type 3 - metabolism Receptor, Fibroblast Growth Factor, Type 4 - metabolism transcription (genetics) tyrosine Viral Proteins - genetics Viral Proteins - metabolism Viral replication Virus Replication
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