Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer

Gastric cancer (GC) is one of the most common malignancies worldwide. Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studies found that Fumarate hydratase (FH) participated in the DNA damage response and its defic...

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Veröffentlicht in:	Cell death & disease 2019-05, Vol.10 (6), p.413
Hauptverfasser:	Yu, Hong-En, Wang, Feng, Yu, Fang, Zeng, Zhao-Lei, Wang, Yun, Lu, Yun-Xin, Jin, Ying, Wang, De-Shen, Qiu, Miao-Zhen, Pu, Heng-Ying, Kang, Tie-Bang, Xie, Dan, Ju, Huai-Qiang, Xu, Rui-Hua, Luo, Hui-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cisplatin Cisplatin - pharmacology Cisplatin - therapeutic use Cytotoxicity DNA damage DNA Damage - drug effects DNA Damage - genetics Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Drug Therapy, Combination Female Fumarase Fumarate Hydratase - antagonists & inhibitors Fumarate Hydratase - genetics Fumarate Hydratase - metabolism Gastric cancer Gene Expression Regulation, Neoplastic - drug effects Humans Mice Mice, Inbred BALB C Mice, Nude Miconazole Prognosis Stomach Neoplasms - drug therapy Stomach Neoplasms - enzymology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Transplantation, Heterologous Tumorigenesis
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