Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer
Gastric cancer (GC) is one of the most common malignancies worldwide. Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studies found that Fumarate hydratase (FH) participated in the DNA damage response and its defic...
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| Veröffentlicht in: | Cell death & disease 2019-05, Vol.10 (6), p.413 |
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| creator | Yu, Hong-En Wang, Feng Yu, Fang Zeng, Zhao-Lei Wang, Yun Lu, Yun-Xin Jin, Ying Wang, De-Shen Qiu, Miao-Zhen Pu, Heng-Ying Kang, Tie-Bang Xie, Dan Ju, Huai-Qiang Xu, Rui-Hua Luo, Hui-Yan |
| description | Gastric cancer (GC) is one of the most common malignancies worldwide. Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studies found that Fumarate hydratase (FH) participated in the DNA damage response and its deficiency was associated with tumorigenesis in some cancers. In this study, we investigated the relationship between FH and cisplatin (CDDP) sensitivity in GC cell lines. We found that FH was the most significant gene which induced by CDDP treatment and the suppression of FH could enhance the cytotoxicity of CDDP. Miconazole Nitrate (MN) could inhibit FH activity and enhance the effect of CDDP in vitro and in vivo. We also investigated the significance of expression of FH in GC tissues. The FH expression, which was higher in GC tissues than in noncancerous tissues, was negatively associated with the prognosis of patients. Together, these results revealed that FH is a reliable indicator for response to CDDP treatment in GC and the inhibition of FH may be a potential strategy to improve the effects of CDDP-based chemotherapy. |
| doi_str_mv | 10.1038/s41419-019-1652-8 |
| format | Article |
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Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studies found that Fumarate hydratase (FH) participated in the DNA damage response and its deficiency was associated with tumorigenesis in some cancers. In this study, we investigated the relationship between FH and cisplatin (CDDP) sensitivity in GC cell lines. We found that FH was the most significant gene which induced by CDDP treatment and the suppression of FH could enhance the cytotoxicity of CDDP. Miconazole Nitrate (MN) could inhibit FH activity and enhance the effect of CDDP in vitro and in vivo. We also investigated the significance of expression of FH in GC tissues. The FH expression, which was higher in GC tissues than in noncancerous tissues, was negatively associated with the prognosis of patients. Together, these results revealed that FH is a reliable indicator for response to CDDP treatment in GC and the inhibition of FH may be a potential strategy to improve the effects of CDDP-based chemotherapy.</description><identifier>EISSN: 2041-4889</identifier><identifier>DOI: 10.1038/s41419-019-1652-8</identifier><identifier>PMID: 31138787</identifier><language>eng</language><publisher>England: Springer Nature B.V</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Apoptosis - drug effects ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chemotherapy ; Cisplatin ; Cisplatin - pharmacology ; Cisplatin - therapeutic use ; Cytotoxicity ; DNA damage ; DNA Damage - drug effects ; DNA Damage - genetics ; Drug Resistance, Neoplasm - drug effects ; Drug Resistance, Neoplasm - genetics ; Drug Therapy, Combination ; Female ; Fumarase ; Fumarate Hydratase - antagonists & inhibitors ; Fumarate Hydratase - genetics ; Fumarate Hydratase - metabolism ; Gastric cancer ; Gene Expression Regulation, Neoplastic - drug effects ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Miconazole ; Prognosis ; Stomach Neoplasms - drug therapy ; Stomach Neoplasms - enzymology ; Stomach Neoplasms - genetics ; Stomach Neoplasms - metabolism ; Transplantation, Heterologous ; Tumorigenesis</subject><ispartof>Cell death & disease, 2019-05, Vol.10 (6), p.413</ispartof><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-9771-8534 ; 0000-0003-4420-5625 ; 0000-0002-4774-6235</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538639/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538639/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31138787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Hong-En</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Yu, Fang</creatorcontrib><creatorcontrib>Zeng, Zhao-Lei</creatorcontrib><creatorcontrib>Wang, Yun</creatorcontrib><creatorcontrib>Lu, Yun-Xin</creatorcontrib><creatorcontrib>Jin, Ying</creatorcontrib><creatorcontrib>Wang, De-Shen</creatorcontrib><creatorcontrib>Qiu, Miao-Zhen</creatorcontrib><creatorcontrib>Pu, Heng-Ying</creatorcontrib><creatorcontrib>Kang, Tie-Bang</creatorcontrib><creatorcontrib>Xie, Dan</creatorcontrib><creatorcontrib>Ju, Huai-Qiang</creatorcontrib><creatorcontrib>Xu, Rui-Hua</creatorcontrib><creatorcontrib>Luo, Hui-Yan</creatorcontrib><title>Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer</title><title>Cell death & disease</title><addtitle>Cell Death Dis</addtitle><description>Gastric cancer (GC) is one of the most common malignancies worldwide. Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studies found that Fumarate hydratase (FH) participated in the DNA damage response and its deficiency was associated with tumorigenesis in some cancers. In this study, we investigated the relationship between FH and cisplatin (CDDP) sensitivity in GC cell lines. We found that FH was the most significant gene which induced by CDDP treatment and the suppression of FH could enhance the cytotoxicity of CDDP. Miconazole Nitrate (MN) could inhibit FH activity and enhance the effect of CDDP in vitro and in vivo. We also investigated the significance of expression of FH in GC tissues. The FH expression, which was higher in GC tissues than in noncancerous tissues, was negatively associated with the prognosis of patients. Together, these results revealed that FH is a reliable indicator for response to CDDP treatment in GC and the inhibition of FH may be a potential strategy to improve the effects of CDDP-based chemotherapy.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Cisplatin - pharmacology</subject><subject>Cisplatin - therapeutic use</subject><subject>Cytotoxicity</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>DNA Damage - genetics</subject><subject>Drug Resistance, Neoplasm - drug effects</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Fumarase</subject><subject>Fumarate Hydratase - antagonists & inhibitors</subject><subject>Fumarate Hydratase - 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Due to the low rate of early detection, most GC patients were diagnosed as advance stages and had poor response to chemotherapy. Some studies found that Fumarate hydratase (FH) participated in the DNA damage response and its deficiency was associated with tumorigenesis in some cancers. In this study, we investigated the relationship between FH and cisplatin (CDDP) sensitivity in GC cell lines. We found that FH was the most significant gene which induced by CDDP treatment and the suppression of FH could enhance the cytotoxicity of CDDP. Miconazole Nitrate (MN) could inhibit FH activity and enhance the effect of CDDP in vitro and in vivo. We also investigated the significance of expression of FH in GC tissues. The FH expression, which was higher in GC tissues than in noncancerous tissues, was negatively associated with the prognosis of patients. Together, these results revealed that FH is a reliable indicator for response to CDDP treatment in GC and the inhibition of FH may be a potential strategy to improve the effects of CDDP-based chemotherapy.</abstract><cop>England</cop><pub>Springer Nature B.V</pub><pmid>31138787</pmid><doi>10.1038/s41419-019-1652-8</doi><orcidid>https://orcid.org/0000-0001-9771-8534</orcidid><orcidid>https://orcid.org/0000-0003-4420-5625</orcidid><orcidid>https://orcid.org/0000-0002-4774-6235</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cisplatin Cisplatin - pharmacology Cisplatin - therapeutic use Cytotoxicity DNA damage DNA Damage - drug effects DNA Damage - genetics Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Drug Therapy, Combination Female Fumarase Fumarate Hydratase - antagonists & inhibitors Fumarate Hydratase - genetics Fumarate Hydratase - metabolism Gastric cancer Gene Expression Regulation, Neoplastic - drug effects Humans Mice Mice, Inbred BALB C Mice, Nude Miconazole Prognosis Stomach Neoplasms - drug therapy Stomach Neoplasms - enzymology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Transplantation, Heterologous Tumorigenesis |
| title | Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer |
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