Creatine based polymer for codelivery of bioengineered MicroRNA and chemodrugs against breast cancer lung metastasis

Metastasis is the major cause for breast cancer related mortality. The combination of miRNA-based therapy and chemotherapy represents a promising approach against breast cancer lung metastasis. The goal of this study is to develop an improved therapy that co-delivers a novel bioengineered miRNA prod...

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Veröffentlicht in:	Biomaterials 2019-07, Vol.210, p.25-40
Hauptverfasser:	Xu, Jieni, Sun, Jingjing, Ho, Pui Yan, Luo, Zhangyi, Ma, Weina, Zhao, Wenchen, Rathod, Sanjay B., Fernandez, Christian A., Venkataramanan, Raman, Xie, Wen, Yu, Ai-Ming, Li, Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bioengineered miRNA prodrug Bioengineering breast neoplasms Breast Neoplasms - pathology Cancer metastasis Cell Line, Tumor Chemo-gene combination therapy composite polymers Creatine Creatine - chemistry Down-Regulation - drug effects doxorubicin Drug Delivery Systems drug therapy Endocytosis - drug effects Female gene expression regulation Humans immune response Lung Neoplasms - drug therapy Lung Neoplasms - secondary metastasis Mice, Inbred BALB C Micelles microRNA MicroRNAs - administration & dosage mortality Multifunctional nanocarriers Nanoparticles - chemistry Polymers - chemical synthesis Polymers - chemistry Tissue Distribution - drug effects
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