Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. Several lines of evidence, from SCLC primary human tumours, patient-derived xenografts, cancer cell lines and genetically engineered mouse models, appear to be converging on a...

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Veröffentlicht in:	Nature reviews. Cancer 2019-05, Vol.19 (5), p.289-297
Hauptverfasser:	Rudin, Charles M., Poirier, John T., Byers, Lauren Averett, Dive, Caroline, Dowlati, Afshin, George, Julie, Heymach, John V., Johnson, Jane E., Lehman, Jonathan M., MacPherson, David, Massion, Pierre P., Minna, John D., Oliver, Trudy G., Quaranta, Vito, Sage, Julien, Thomas, Roman K., Vakoc, Christopher R., Gazdar, Adi F.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1612/2143 631/67/1857 631/67/69 Animal models Animals ASCL1 protein Beta2 protein Biomedical and Life Sciences Biomedicine Cancer Research Carboplatin Care and treatment Gene Expression Regulation, Neoplastic Genetic aspects Genetic engineering Genetically modified mice Genetically modified organisms Heterografts - pathology Homeobox Homology Humans Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Malignancy Mice Perspective Small cell lung cancer Small cell lung carcinoma Small Cell Lung Carcinoma - genetics Small Cell Lung Carcinoma - pathology Transcription Transcription (Genetics) Transcription Factors - genetics Transcription, Genetic - genetics Tumor cell lines Tumors Xenografts Yes-associated protein
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