Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: Role of corticosterone, oxytocin, and vasopressin

Background: The chronobiotic antidepressant, agomelatine, acts via re-entrainment of circadian rhythms. Earlier work has demonstrated late-life anxiety and reduced corticosterone in post-weaning social isolation reared (SIR) rats. Agomelatine was anxiolytic in this model but did not reverse hypocort...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2019-05, Vol.33 (5), p.640-646
Hauptverfasser:	Harvey, Brian H, Regenass, Wilmie, Dreyer, Walter, Möller, Marisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - administration & dosage Acetamides - pharmacology Animals Anti-Anxiety Agents - administration & dosage Anti-Anxiety Agents - pharmacology Antidepressants Anxiety Anxiety - blood Anxiety - drug therapy Anxiety - etiology Anxiolytics Behavior, Animal Circadian rhythm Circadian rhythms Corticosterone Corticosterone - blood Entrainment Female Male Oxytocin Oxytocin - blood Oxytocin - drug effects Rats Rats, Sprague-Dawley Reentrainment Rodents Sex differences Short Report Social interactions Social Isolation Variation Vasopressin Vasopressins - blood Vasopressins - drug effects Weaning
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