Synergic Effect of Allopurinol in Combination with Nitroheterocyclic Compounds against Trypanosoma cruzi

Combination therapy has gained attention as a possible strategy for overcoming the limitations of the present therapeutic arsenal for Chagas disease. The aim of this study was to evaluate the effect of allopurinol in association with nitroheterocyclic compounds on infection with the Y strain of The...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2019-06, Vol.63 (6)
Hauptverfasser:	Mazzeti, Ana Lia, Diniz, Lívia de F, Gonçalves, Karolina R, WonDollinger, Ruan Schott, Assíria, Tassiane, Ribeiro, Isabela, Bahia, Maria T
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopurinol Allopurinol - therapeutic use Animals Cell Line Chagas Disease - parasitology Experimental Therapeutics Humans Mice Mortality Nifurtimox Nifurtimox - therapeutic use Nitroimidazoles Nitroimidazoles - therapeutic use Real-Time Polymerase Chain Reaction Trypanosoma cruzi - drug effects Trypanosoma cruzi - pathogenicity
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