Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins

Canonical Wnt signaling is emerging as a major regulator of endocytosis. Wnt treatment markedly increased the endocytosis and degradation in lysosomes of BSA. In this study, we report that in addition to receptor-mediated endocytosis, Wnt also triggers the intake of large amounts of extracellular fl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-05, Vol.116 (21), p.10402-10411
Hauptverfasser:	Tejeda-Muñoz, Nydia, Albrecht, Lauren V., Bui, Maggie H., De Robertis, Edward M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adenomatous polyposis coli Amiloride Animals Arginine Axin Protein - metabolism beta Catenin - metabolism Biodegradation Biological Sciences Cancer Cell Line Cell Line, Tumor Colorectal carcinoma Degradation Depletion Dextran Diuretics Endocytosis Endocytosis - physiology Frizzled protein Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 - metabolism Glycoproteins Glycoproteins - metabolism HeLa Cells Humans Kinases Lysosomes Lysosomes - metabolism Metabolism Methyltransferase Mice Molecular weight Na+/H+-exchanging ATPase Neoplasms - metabolism NIH 3T3 Cells Nuclei (cytology) Nutrients Pinocytosis - physiology PNAS Plus Polyposis coli Protein biosynthesis Protein synthesis Protein transport Protein-Arginine N-Methyltransferases - metabolism Proteins Signal transduction Signaling Suppressors Switches Trans-Activators - metabolism Transcription Wnt protein Wnt Proteins - metabolism Wnt Signaling Pathway - physiology β-Catenin
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