Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes

While polymeric nano-formulations for RNAi therapeutics hold great promise for molecularly-targeted, personalized medicine, they possess significant systemic delivery challenges including rapid clearance from circulation and the potential for carrier-associated toxicity due to cationic polymer or li...

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Veröffentlicht in:	Biomaterials 2019-02, Vol.192, p.245-259
Hauptverfasser:	Jackson, Meredith A., Bedingfield, Sean K., Yu, Fang, Stokan, Mitchell E., Miles, Rachel E., Curvino, Elizabeth J., Hoogenboezem, Ella N., Bonami, Rachel H., Patel, Shrusti S., Kendall, Peggy L., Giorgio, Todd D., Duvall, Craig L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cations - chemistry Cell Line, Tumor Drug delivery Dual hydrophobization Female Humans Hydrophobic and Hydrophilic Interactions Mice, Inbred BALB C Mice, Nude Nanostructures - chemistry Neoplasms - therapy Pharmacokinetics Polymers - chemistry RNA interference RNA, Small Interfering - administration & dosage RNA, Small Interfering - pharmacokinetics RNAi Therapeutics Tissue Distribution Toxicology Zwitterionic polyplexes
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